Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2tm1Gak mutation
(1 available);
any
Lcp2 mutation
(41 available)
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mortality/aging
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• there is a selective loss of homozygous progeny observed
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hematopoietic system
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• platelets fail to activate in response to plating on lymphatic microvascular endothelial cells (LEC) unlike wild-type cells
• platelets from neonates without vascular phenotypes exhibit low levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells
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• platelets fail to form aggregates on microvascular endothelial cells (LEC) under flow unlike similarly treated wild-type cells
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homeostasis/metabolism
immune system
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• at E14.5, mice exhibit blood-filled cutaneous lymphatics unlike in wild-type mice
• neonates exhibit blood-filled mesenteric lymphatics unlike in wild-type mice
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digestive/alimentary system
homeostasis/metabolism
immune system
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• some mice exhibit blood-filled Peyer patches unlike in wild-type mice
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• mice exhibit blood-filled mesenteric and intestinal lymphatic vessels unlike wild-type mice
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homeostasis/metabolism
hematopoietic system
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• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells
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hematopoietic system
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• no double positive or single positive T cells are detected in triple mutants
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immune system
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• no double positive or single positive T cells are detected in triple mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbltm1.1Hua mutation
(0 available);
any
Cbl mutation
(57 available)
Lcp2tm1Gak mutation
(1 available);
any
Lcp2 mutation
(41 available)
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immune system
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• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type
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• double knockouts generate significant proportions of double positive and Cd4+CD8- T cells compared to Lcp knockouts; these populations are significantly lower than those expected in wild-type or Cbl-null mice
• expression of CD3 or Tcrb is decreased on thymic CD4+CD8- cells compared to wild-type cells; expression of CD4 and CD69 is increased on double positive and single positive CD4 thymocytes relative to wild-type
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• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice; numbers are ~10x the number observed in wild-type or Cbl-null mice at 24 weeks of age
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• many more CD4+ cells produce Il-2, Il-4 and Ifng compared to wild-type
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• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma
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• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles
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hematopoietic system
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• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type
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• double knockouts generate significant proportions of double positive and Cd4+CD8- T cells compared to Lcp knockouts; these populations are significantly lower than those expected in wild-type or Cbl-null mice
• expression of CD3 or Tcrb is decreased on thymic CD4+CD8- cells compared to wild-type cells; expression of CD4 and CD69 is increased on double positive and single positive CD4 thymocytes relative to wild-type
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• mutants have elevated levels of CD4+ T cells in the spleen and lymph nodes of 6 week old mice compared to wild-type or Cbl-null mice; numbers are ~10x the number observed in wild-type or Cbl-null mice at 24 weeks of age
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liver/biliary system
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• extensive lymphocyte infiltration is observed in the liver of mutants; lymphocytes are observed as clusters around hepatic parenchyma
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respiratory system
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• extensive lymphocyte infiltration is observed in the lungs of mutants; lymphocytes are observed as clusters around pulmonary vessels and bronchioles
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growth/size/body
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• mice develop progressive splenomegaly with age and die at ~6 months of age: mutants have 8-12 times the number of splenic CD4+ cells compared to wild-type
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