All Phenotypes Tcf7<tm1Cle> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf7^tm1Cle/Tcf7^tm1Cle	involves: 129P2/OlaHsd	MGI:4360712
cn2	Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tg(Vil1-cre/ERT2)23Syr/0	involves: 129 * C57BL/6 * DBA/2	MGI:5430371
cn3	Lef1^tm1Hhx/Lef1^tm1Hhx Tcf7^tm1Cle/Tcf7^tm1Cle Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺ Tg(GZMB-cre)1Jcb/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5447982
cn4	Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle Tg(Vil1-cre/ERT2)23Syr/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5430369
cx5	Lef1^tm1Rug/Lef1^tm1Rug Tcf7^tm1Cle/Tcf7^tm1Cle	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5319647
cx6	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tcf7^tm1Cle/Tcf7⁺	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5319651
cx7	Apc^Min/Apc⁺ Tcf7^tm1Cle/Tcf7^tm1Cle	involves: 129P2/OlaHsd * C57BL/6J	MGI:5319648

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus cortex hypoplasia ( J:23255 )

• cortex of the thymus is underdeveloped

thymus hypoplasia ( J:23255 )

• thymus cellularity is reduced 10- to a 100- fold compared to controls

abnormal T cell differentiation ( J:23255 )

• cell cycling is less robust than controls in thymocytes progressing from the double-negative stage through the intermediate single-positive stage

decreased double-positive T cell number ( J:23255 )

• absolute numbers of double-positive thymocytes are reduced 100-fold compared to controls

decreased T cell number ( J:23255 )

• T cell numbers in the lymph node and spleen are reduced 10-fold and 3-fold, respectively

• ratios of the T cell subsets are unaffected

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased CD8+ effector T in the peripheral blood lymphocytes and spleen compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

decreased single-positive T cell number ( J:23255 )

• absolute numbers of single-positive thymocytes are reduced 100-fold compared to controls

increased osteoclast cell number ( J:98430 )

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

skeleton

increased osteoclast cell number ( J:98430 )

decreased bone mineral density ( J:98430 )

• low bone density at 1 month of age

neoplasm

increased intestinal adenoma incidence ( J:57721 )

• polyp-like intestinal neoplasms

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas

hematopoietic system

thymus cortex hypoplasia ( J:23255 )

• cortex of the thymus is underdeveloped

thymus hypoplasia ( J:23255 )

• thymus cellularity is reduced 10- to a 100- fold compared to controls

abnormal T cell differentiation ( J:23255 )

• cell cycling is less robust than controls in thymocytes progressing from the double-negative stage through the intermediate single-positive stage

decreased T cell number ( J:23255 )

• T cell numbers in the lymph node and spleen are reduced 10-fold and 3-fold, respectively

• ratios of the T cell subsets are unaffected

decreased double-positive T cell number ( J:23255 )

• absolute numbers of double-positive thymocytes are reduced 100-fold compared to controls

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased CD8+ effector T in the peripheral blood lymphocytes and spleen compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin

decreased single-positive T cell number ( J:23255 )

• absolute numbers of single-positive thymocytes are reduced 100-fold compared to controls

increased osteoclast cell number ( J:98430 )

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

endocrine/exocrine glands

thymus cortex hypoplasia ( J:23255 )

• cortex of the thymus is underdeveloped

thymus hypoplasia ( J:23255 )

• thymus cellularity is reduced 10- to a 100- fold compared to controls

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas

integument

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas

digestive/alimentary system

increased intestinal adenoma incidence ( J:57721 )

• polyp-like intestinal neoplasms

Allelic Composition	Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1^tm1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:185753 )

N	• tamoxifen-treated mice exhibit normal adult intestinal homeostasis

Allelic Composition	Lef1^tm1Hhx/Lef1^tm1Hhx Tcf7^tm1Cle/Tcf7^tm1Cle Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺ Tg(GZMB-cre)1Jcb/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Sho mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Lef1^tm1Hhx mutation (2 available); any Lef1 mutation (42 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)
Tg(GZMB-cre)1Jcb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7^tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin

• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7^tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

decreased tumor necrosis factor secretion ( J:189838 )

• from CD8+ effector T cells following infection with actA- L. monocytogenes-expressing ovalbumin

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:189838 )

• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7^tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin

abnormal memory T cell physiology ( J:189838 )

• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

Allelic Composition	Tcf7^tm1Cle/Tcf7^tm1Cle Tcf7l1^tm1Efu/Tcf7l1^tm1Efu Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1^tm1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tcf7l2^tm2.1Cle mutation (0 available); any Tcf7l2 mutation (56 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system morphology ( J:185753 )

• tamoxifen-treatment results in the same defects as in Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle Tg(Vil-cre/ERT2)23Syr mice

abnormal digestive system physiology ( J:185753 )

• tamoxifen-treatment results in the same defects as in Tcf7l2^tm2.1Cle/Tcf7l2^tm2.1Cle Tg(Vil-cre/ERT2)23Syr mice

Allelic Composition	Lef1^tm1Rug/Lef1^tm1Rug Tcf7^tm1Cle/Tcf7^tm1Cle
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lef1^tm1Rug mutation (0 available); any Lef1 mutation (42 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:54101 )

• homozygotes are found at normal frequencies at E6.5 and E9.5

• found in reduced numbers after E10.5

embryo

abnormal embryonic tissue morphology ( J:54101 )

• caudal defects seen at E9.5

abnormal limb bud morphology ( J:54101 )

• limb bud defects seen at E9.5

absent apical ectodermal ridge ( J:54101 )

small forelimb buds ( J:54101 )

• forelimbs reduced in size at E9.5

abnormal ectomesenchyme morphology ( J:54101 )

• no mesenchymal cells form under the ectoderm in the primitive streak region as occurs in controls

abnormal neural tube morphology ( J:54101 )

• ectopic neural tubes form caudally in place of somites

incomplete somite formation ( J:54101 )

• abnormal somites anterior to the forelimb buds

• no caudal region somites

abnormal extraembryonic tissue morphology ( J:54101 )

abnormal allantois morphology ( J:54101 )

• abnormal masses of cells form

limbs/digits/tail

abnormal limb bud morphology ( J:54101 )

• limb bud defects seen at E9.5

absent apical ectodermal ridge ( J:54101 )

small forelimb buds ( J:54101 )

• forelimbs reduced in size at E9.5

nervous system

abnormal neural tube morphology ( J:54101 )

• ectopic neural tubes form caudally in place of somites

small embryonic telencephalon ( J:54101 )

growth/size/body

abnormal ectomesenchyme morphology ( J:54101 )

• no mesenchymal cells form under the ectoderm in the primitive streak region as occurs in controls

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tcf7^tm1Cle/Tcf7⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:98430 )

• very low bone density

Allelic Composition	Apc^Min/Apc⁺ Tcf7^tm1Cle/Tcf7^tm1Cle
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Tcf7^tm1Cle mutation (0 available); any Tcf7 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:57721 )

• adenomatous polyps form throughout the intestine

• large in size but showing no signs of tumor progression

increased salivary gland tumor incidence ( J:57721 )

• 60% of mice with adenomas and adenoacanthomas of the salivary glands at 6 months of age

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas in the mammary glands of all female mice by 8 weeks of age

• also in older male mice

digestive/alimentary system

increased intestinal adenoma incidence ( J:57721 )

• adenomatous polyps form throughout the intestine

• large in size but showing no signs of tumor progression

increased salivary gland tumor incidence ( J:57721 )

• 60% of mice with adenomas and adenoacanthomas of the salivary glands at 6 months of age

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:57721 )

• 60% of mice with adenomas and adenoacanthomas of the salivary glands at 6 months of age

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas in the mammary glands of all female mice by 8 weeks of age

• also in older male mice

integument

increased mammary adenoacanthoma incidence ( J:57721 )

• adenoacanthomas in the mammary glands of all female mice by 8 weeks of age

• also in older male mice

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