Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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nervous system
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• 7 days after traumatic spinal cord injury increased cell death is seen in the spinal cord compared to wild-type or Tnfrsf1btm1Mwm homozygotes
• 7 days after traumatic spinal cord injury the rostrocaudal spread of the lesion is increased and tissue destruction is more severe compared to wild-type mice
• 4 weeks after traumatic spinal cord injury locomotor performance is significantly more impaired and lesions are longer
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behavior/neurological
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• after sleep deprivation, mice exhibit increased slow 'slow waves' and negative rebound during the dark period unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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mortality/aging
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• decreased mortality is seen after exposure to 750 mg acetaminophen /kg
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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Germinal centers and follicular dendritic cell networks are absent in Tnfrsf1atm1Blt/Tnfrsf1atm1Blt mice immunized with sheep red blood cells
mortality/aging
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• all mice infected with Listeria monocytogenes die unlike wild-type mice
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• no mice treated with TNF die unlike wild-type mice
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immune system
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• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice
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• all mice infected with Listeria monocytogenes die unlike wild-type mice
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homeostasis/metabolism
cellular
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• in mouse embryonic fibroblasts exposed to hypoxia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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immune system
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• organized follicular dendritic cell networks are absent
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• the typical subepithelial dome areas fail to form
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• B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent
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• average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice
• however, T cell populations in the thymus and T and B cell populations in the spleen and lymph nodes are normal
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• B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however B cells are present and B and T cell areas are segregated
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• following treatment with MOG
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• significant reduction in bronchoalveolar lavage leukocytosis in an ovalbumin-induced allergic asthma model
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• LPS-induced IL-6 secretion is reduced about 3-fold compared to wild-type mice; however TNF secretion is similar to wild-type
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• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice
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• infection with as few as 250 colony forming units of Listeria monocytogenes results in 100% mortality by 6 days after infection, all wild-type mice survive this treatment
• D-galactosamine sensitized homozygotes can survive 100-fold higher concentrations of LPS than wild-type; however without D-galactosamine sensitization both types of mice show similar sensitivity to LPS-induced mortality
• however, homozygotes are able to control infections of lymphocytic choriomeningitis virus
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• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice
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hematopoietic system
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• following treatment with MOG
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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homeostasis/metabolism
immune system
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• mice exhibit reduced Pseudomonas aerugiosa exotoxin-induced liver failure compared with similarly treated wild-type mice
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Allelic
Composition |
Tnfrsf1atm1Blt/Tnfrsf1a+
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Genetic
Background |
involves: 129P2/OlaHsd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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mortality/aging
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• no mice treated with TNF die unlike all wild-type mice
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immune system
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• decreased induction in TNF-treated mice
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homeostasis/metabolism
immune system
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N |
• architecture of all secondary lymphoid organs is similar to wild-type
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immune system
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• despite the absence of germinal centers the white pulp has distinct T and B cell areas
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• grossly unidentifiable and histologically hypoplastic
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• thin and lack primary and secondary cortical follicles
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• develop severe inflammation 4 weeks after infection with Pneumocystis carinii
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• 4 weeks after infection with Pneumocystis carinii lungs demonstrate severe infection indicating mice are unable to clear the infection
• 4 weeks after infection with Pneumocystis carinii pulmonary lavages contain about 10 fold higher numbers of leukocytes compared to similarly infected control mice
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hematopoietic system
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• in pulmonary lavage fluid 4 weeks after infection with Pneumocystis carinii relative to infected controls
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• despite the absence of germinal centers the white pulp has distinct T and B cell areas
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respiratory system
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• develop severe inflammation 4 weeks after infection with Pneumocystis carinii
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immune system
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N |
• mice are able to clear infections of Pneumocystis carinii similar to controls
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• despite the absence of germinal centers the white pulp has distinct T and B cell areas
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• following treatment with MOG
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• grossly unidentifiable and histologically hypoplastic
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• thin and lack primary and secondary cortical follicles
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• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, a 6-fold reduction in demyelination area, and decreased MOG-specific IgG response but increased number of inflammatory foci compared with similarly treated wild-type mice
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• T. gondii-exposed mice exhibit increased bacterial load compared with similarly treated wild-type mice
• however, recruitment and intracerebral cell movement is normal in T. gondii-exposed mice
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hematopoietic system
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• despite the absence of germinal centers the white pulp has distinct T and B cell areas
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• following treatment with MOG
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immune system
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• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice
• however, no signs of arthritis or inflammatory bowel disease are detected
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• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation
(1 available)
Tnfrsf1atm1Blt mutation
(6 available);
any
Tnfrsf1a mutation
(47 available)
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nervous system
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• neurological symptoms by the sixth month of age, delayed compared to Tg alone
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• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord
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Analysis Tools