All Phenotypes Nos2<tm1Lau> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nos2^tm1Lau
targeted mutation 1, Victor E Laubach
MGI:1857228

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nos2^tm1Lau/Nos2^tm1Lau	B6.129P2-Nos2^tm1Lau	MGI:3621556
hm2	Nos2^tm1Lau/Nos2^tm1Lau	B6;129P2-Nos2^tm1Lau/J	MGI:4367729
hm3	Nos2^tm1Lau/Nos2^tm1Lau	B6.129P2-Nos2^tm1Lau/J	MGI:3794771
hm4	Nos2^tm1Lau/Nos2^tm1Lau	involves: 129P2/OlaHsd	MGI:4366786
hm5	Nos2^tm1Lau/Nos2^tm1Lau	involves: 129P2/OlaHsd * C57BL/6	MGI:2174977
hm6	Nos2^tm1Lau/Nos2^tm1Lau	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366787
cx7	Nos2^tm1Lau/Nos2^tm1Lau Nos3^tm1Unc/Nos3^tm1Unc	B6.129P2-Nos3^tm1Unc Nos2^tm1Lau	MGI:4367219
cx8	Apc^Min/Apc⁺ Nos2^tm1Lau/Nos2^tm1Lau	B6.Cg-Nos2^tm1Lau Apc^Min	MGI:3767791
cx9	Apc^Min/Apc⁺ Nos2^tm1Lau/Nos2⁺	B6.Cg-Nos2^tm1Lau Apc^Min	MGI:3767792
cx10	Nos2^tm1Lau/Nos2^tm1Lau Tg(MMTV-PyVT)634Mul/0	B6.Cg-Nos2^tm1Lau Tg(MMTV-PyVT)634Mul	MGI:3767793
cx11	Nos2^tm1Lau/Nos2^tm1Lau Tg(MMTV-PyVT)634Mul/0	FVB.Cg-Nos2^tm1Lau Tg(MMTV-PyVT)634Mul	MGI:3767794
cx12	Adh5^tm1Stam/Adh5^tm1Stam Nos2^tm1Lau/Nos2^tm1Lau	involves: 129 * 129P2/OlaHsd	MGI:5049930
cx13	Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Lau/Nos2^tm1Lau	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J	MGI:4367217
cx14	Il10^tm1Cgn/Il10^tm1Cgn Nos2^tm1Lau/Nos2^tm1Lau	involves: 129P2/OlaHsd * C57BL/6	MGI:4460234
cx15	Nos2^tm1Lau/Nos2^tm1Lau Tg(RHO-VEGFA)V-6Camp/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:4366933
cx16	Nos2^tm1Lau/Nos2^tm1Lau Tg(APPSWE)2576Kha/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3769910
cx17	Nos2^tm1Lau/Nos2^tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?	involves: C57BL/6	MGI:3829507

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	B6.129P2-Nos2^tm1Lau

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:115413 )

N	• better survival after myocardial infarction than for wild-type controls

increased mortality induced by ionizing radiation ( J:98135 )

• increased sensitivity to ionizing radiation

cardiovascular system

cardiovascular system phenotype ( J:106207 )

N	• unlike mice null for Nos3, ischemia induced retinal neovascularization is not significantly different from controls

decreased susceptibility to induced choroidal neovascularization ( J:106207 )

• choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced

abnormal physiological neovascularization ( J:98135 )

• retinal revascularization after ischemia produces small highly branched blood vessels

• three fold more branching occurs in revascularization than occurs in controls

abnormal heart morphology ( J:108269 )

abnormal myocardium layer morphology ( J:71505 )

• increased hyalination and patchy loss of cross-striations when on 100% oxygen

abnormal heart ventricle morphology ( J:108269 )

• hypoxia causes less increase in the RV/LV+Septum ratio than is found in controls

increased left ventricle developed pressure ( J:115413 )

• left ventricular maximum developed pressure was similar to sham operated animals 4 months after myocardial infarction rather than being reduced as in wild-type controls

decreased systemic arterial systolic blood pressure ( J:104749 )

• more significant drop in systolic blood pressure after myocardial infarction than is seen in controls

vision/eye

decreased susceptibility to induced choroidal neovascularization ( J:106207 )

• choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced

nervous system

increased susceptibility to pharmacologically induced seizures ( J:107300 )

• shortened latency to seizures induced by kainic acid when on a normal diet

• behavior responses correspond to grade V seizures

• latency to seizure is prolonged when fed a ketogenic diet

abnormal corpus callosum morphology ( J:125459 )

• increased myelin pathology after treatment with cuprizone

decreased oligodendrocyte number ( J:125459 )

• decreased numbers of mature oligodendrocytes after cuprizone treatment

• numbers of oligodendrocytes reduced to 50% of controls after 3.5 weeks

• undergo increased apoptosis which is not seen for microglia and astrocytes

enhanced central nervous system regeneration ( J:110081 )

• recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less

digestive/alimentary system

decreased susceptibility to induced colitis ( J:87601 )

• less susceptibility to dextran sodium sulfate induced colitis

• less severe weight loss, blood loss and macroscopic damage

• improved survival

homeostasis/metabolism

abnormal blood coagulation ( J:117987 )

• shorter time to thrombus formation and vessel occlusion

abnormal platelet physiology ( J:117987 )

• increased platelet deposition

abnormal glucose homeostasis ( J:95957 )

• no effect on streptozotocin induced diabetis

increased mortality induced by ionizing radiation ( J:98135 )

• increased sensitivity to ionizing radiation

enhanced wound healing ( J:110081 )

• recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:107300 )

• shortened latency to seizures induced by kainic acid when on a normal diet

• behavior responses correspond to grade V seizures

• latency to seizure is prolonged when fed a ketogenic diet

abnormal eating behavior ( J:112153 )

• inhibitory effect of insulin on feeding is enhanced by 10 ^-8M TNF alpha

abnormal frequency of paradoxical sleep ( J:83571 )

• significantly more time spent in REM sleep during the light period

• increased REM sleep results from more REM episodes and shortened periods in between

• more non REM sleep episodes in light period but of shorter duration

• significantly less non REM sleep during dark periods

respiratory system

respiratory system phenotype ( J:71505 )

N	• alveolar fluid clearance unaffected by amilorid and forskolin which both affect clearance in controls

abnormal respiratory bronchiole morphology ( J:71505 )

• increased ulceration in 100% oxygen than seen with controls

abnormal respiratory system physiology ( J:71505 )

• reduced lung injury relative to controls after 55 hours at 100% oxygen

immune system

decreased susceptibility to induced colitis ( J:87601 )

• less susceptibility to dextran sodium sulfate induced colitis

• less severe weight loss, blood loss and macroscopic damage

• improved survival

abnormal osteoclast morphology ( J:112399 )

• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading

hematopoietic system

abnormal osteoclast morphology ( J:112399 )

• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading

abnormal platelet physiology ( J:117987 )

• increased platelet deposition

skeleton

abnormal bone structure ( J:112399 )

• less recovery of lost bone volume due to bone unloading 7 days after reloading

abnormal osteoclast morphology ( J:112399 )

• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading

abnormal bone mineralization ( J:112399 )

• lower mineral aposition rate than in controls 7 days after bone reloading

muscle

abnormal myocardium layer morphology ( J:71505 )

• increased hyalination and patchy loss of cross-striations when on 100% oxygen

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	B6;129P2-Nos2^tm1Lau/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:148923 )

• following hepatic ischemia and reperfusion compared with similarly treated wild-type mice

decreased circulating aspartate transaminase level ( J:148923 )

• following hepatic ischemia and reperfusion compared with similarly treated wild-type mice

decreased susceptibility to injury ( J:148923 )

• following hepatic ischemia and reperfusion, mice exhibit reduced liver injury with improved histology due to only mild signs of vascular changes, necrosis, and apoptosis and decreased serum alanine and aspartate transferase levels, and leukocyte (neutrophils, CD3 lymphocytes, CD4 T cells, and granulocytes) recruitment compared with similarly treated wild-type mice

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	B6.129P2-Nos2^tm1Lau/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal surfactant physiology ( J:130520 )

• following infection with mycoplasma, the numbers of large surfactant aggregates is decreased and higher protein to lipid ratios are present in the bronchoalveolare lavage fluid compared to similarly infected wild-type mice

• following infection with mycoplasma, the minimal surface area on the pulsating bubble is increased and the levels of surfactant protein are decreased compared to similarly infected wild-type mice

behavior/neurological

abnormal sleep pattern ( J:83571 )

• mice spend more time in REM sleep during the light phase as a result of an increased number of REM episodes and shortened duration of the inter REM intervals

• mice spend less time in non-REM sleep during the dark phase

• during the light phase mice spend the same amount of time in non-REM sleep but have a higher number of non-REM episodes of shorter average duration

abnormal circadian sleep/wake cycle ( J:83571 )

• mice display a more pronounced diurnal variation of sleep-wake activity

nervous system

abnormal brain wave pattern ( J:83571 )

• during non-REM sleep the absolute value of slow wave activity is increased

immune system

abnormal inflammatory response ( J:103018 )

• unlike in wild-type mice, LPS injection fails to reduce nighttime body temperature relative to saline injected controls

decreased inflammatory response ( J:103018 )

• fever in response to LPS injection is partially reduced compared to wild-type controls

• the fever response to LPS is initiated but not sustained

• however, fever in response to turpentine injection is not different from controls

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:55936 )

N	• unlike in mice null for Nos1 or Nos3, no abnormalities in leukocyte rolling or adhesion are detected

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:120673 )

• reduced survival 8 days after 30 minutes of experimentally induced kidney eschemia relative to controls

cardiovascular system

cardiovascular system phenotype ( J:36559 )

N	• blood pressure and heart rate are normal

abnormal systemic arterial blood pressure ( J:106197 )

• blood pressure drops less in response to LPS injection than it does in controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:113106 )

N	• after injection of platelet-activating factor (PAF), >90% mortality occurs within 30 minutes, similar to wild-type controls • pretreatment with wortmannin before PAF treatment confers 100% protection to mutants and wild-type

abnormal blood homeostasis ( J:120673 )

increased circulating creatinine level ( J:120673 )

• higher plasma creatinine levels 24 hours after experimentally induced kidney eschemia than in controls

increased circulating antidiuretic hormone level ( J:106197 )

• elevation in plasma AVP due to LPS injection persists longer than controls, still significantly elevated after 6 hours whereas levels more moderately elevated in controls aftr 4 hours.

decreased circulating leptin level ( J:94571 )

• plasma leptin concentrations are significantly reduced

abnormal enzyme/coenzyme level ( J:120673 )

• elevated tissue myeloperoxidase levels relative to controls 9 days after kidney eschemia

improved glucose tolerance ( J:72215 )

• hyperglycemic in the first 30 minutes of a glucose tolerance test

• return to fasting glucose levels by 90 minutes when controls are still hyperglycemic

increased insulin sensitivity ( J:72215 )

immune system

immune system phenotype ( J:29677 , J:64036 )

N	• homozygotes are indistinguishable from wild-type in appearance, histology, growth rate, reproduction, and in mortality in an LPS-induced model of septic shock (J:29677) • growth of Mycobacterium leprae unaffected (J:64036)

abnormal immune system morphology ( J:90903 )

increased single-positive T cell number ( J:90903 )

• increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes

enlarged inguinal lymph nodes ( J:90903 )

• increased cellularity of inguinal lymph nodes

abnormal adaptive immunity ( J:90903 )

• primary immune responses are unaffected

increased T cell proliferation ( J:90903 )

• increased T-cell proliferative response to protein antigens

• "clonal burst size" is unchanged

skin inflammation ( J:64036 )

• greatly increased granulomatous inflammation when infected with Mycobacterium leprae

• resembles borderline tuberculoid lesions of leprosy

increased susceptibility to bacterial infection ( J:100513 )

• intracellular growth of Mycobacterium tuberculosis and Francisella tularensis is increased but to highly variable extent

neoplasm

abnormal tumor susceptibility ( J:93780 )

• increased rate of growth of ascites tumor cells

• no apoptosis in ascites tumor cells 2 weeks after innoculation

• growth of solid tumors from ascites tumor cells is prevented

adipose tissue

decreased white adipose tissue amount ( J:94571 )

• reduced amounts of epididymal white adipose tissue

reproductive system

abnormal reproductive system morphology ( J:84347 )

abnormal testis morphology ( J:84347 )

enlarged seminiferous tubules ( J:84347 )

• significantly increased diameter and volume

increased testis weight ( J:84347 )

• 31% increase

abnormal gametogenesis ( J:84347 )

abnormal male meiosis ( J:84347 )

• numbers of pachytene spermatocytes and round spermatids are increased

• decreased apoptosis of pachytene, early round spermatids at stages I-IV, and diplotene dividing spermatocytes at stages XI-XII

• reduced heat induced apoptosis

increased sperm number ( J:84347 )

• 65.5% increase in sperm content

abnormal fertilization ( J:112824 )

• significantly higher numbers of 2-celled embryos produced when homozygotes are intercrossed

• blastocyst formation is similar to controls

• fertilization rate of mutant sperm and normal ova is significantly higher than controls

• fertilization rate of mutant ova and normal sperm is much higher than controls

endocrine/exocrine glands

abnormal testis morphology ( J:84347 )

enlarged seminiferous tubules ( J:84347 )

• significantly increased diameter and volume

increased testis weight ( J:84347 )

• 31% increase

hematopoietic system

increased T cell proliferation ( J:90903 )

• increased T-cell proliferative response to protein antigens

• "clonal burst size" is unchanged

increased single-positive T cell number ( J:90903 )

• increased numbers of both CD4+ and CD8+ cells in inguinal lymph nodes

growth/size/body

increased growth rate ( J:72215 )

• experience greater weight gain on a high fat diet

behavior/neurological

increased food intake ( J:72215 )

• consume 1.6 times as much food as controls on a high fat diet

integument

skin inflammation ( J:64036 )

• greatly increased granulomatous inflammation when infected with Mycobacterium leprae

• resembles borderline tuberculoid lesions of leprosy

cellular

abnormal male meiosis ( J:84347 )

• numbers of pachytene spermatocytes and round spermatids are increased

• decreased apoptosis of pachytene, early round spermatids at stages I-IV, and diplotene dividing spermatocytes at stages XI-XII

• reduced heat induced apoptosis

increased T cell proliferation ( J:90903 )

• increased T-cell proliferative response to protein antigens

• "clonal burst size" is unchanged

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine pH ( J:64896 )

• small but significant increase in urine pH and bicarbonate concentration

homeostasis/metabolism

increased urine pH ( J:64896 )

• small but significant increase in urine pH and bicarbonate concentration

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Nos3^tm1Unc/Nos3^tm1Unc
Genetic Background	B6.129P2-Nos3^tm1Unc Nos2^tm1Lau

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Nos3^tm1Unc mutation (6 available); any Nos3 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83112 )

• fewer than expected double homozygotes are born, no time of lethality provided

Allelic Composition	Apc^Min/Apc⁺ Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	B6.Cg-Nos2^tm1Lau Apc^Min

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:73152 )

• polyp size reduced

decreased tumor incidence ( J:73152 )

• 29% of tumor incidence observed in controls

• multiplicity of tumors reduced to about 9% of control level

Allelic Composition	Apc^Min/Apc⁺ Nos2^tm1Lau/Nos2⁺
Genetic Background	B6.Cg-Nos2^tm1Lau Apc^Min

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:73152 )

• polyp size reduced

decreased tumor incidence ( J:73152 )

• 68% of tumor incidence observed in controls

• multiplicity of tumors reduced to about 33% of control level

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Tg(MMTV-PyVT)634Mul/0
Genetic Background	B6.Cg-Nos2^tm1Lau Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:121391 )

• Background Sensitivity: moderate rate of growth of tumors after reaching 1 cubic cm relative to FVB mice

decreased tumor incidence ( J:121391 )

• Background Sensitivity: fewer tumors develop than in FVB mice

increased tumor latency ( J:84218 , J:121391 )

• slower to develop mammary tumors (J:84218)

• delayed tumor development relative to FVB mice (J:84218)

• Background Sensitivity: delay in palpable tumor development of 3-4 weeks relative to mice on a FVB background (J:121391)

• Background Sensitivity: latency to tumors of 92 days (J:121391)

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.Cg-Nos2^tm1Lau Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:121391 )

• Background Sensitivity: exponential growth of tumors after reaching 1cubic cm

increased tumor incidence ( J:121391 )

• Background Sensitivity: more tumors appear than in mice on a B6 background

decreased tumor latency ( J:121391 )

• palpable tumor development is more rapid than in mice on a B6 background; latency to tumor appearance is ~53 days

Allelic Composition	Adh5^tm1Stam/Adh5^tm1Stam Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5^tm1Stam mutation (1 available); any Adh5 mutation (27 available)
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:173666 )

N	• mice exhibit normal survival following diethylnitrosamine (DEN) challenged

Allelic Composition	Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1^tm1Plh mutation (3 available); any Nos1 mutation (82 available)
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83112 )

• fewer than expected double homozygotes are born, no time of lethality provided

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Nos2^tm1Lau/Nos2^tm1Lau
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased myocardial infarct size ( J:70292 )

• 120% more necrosis after experimental ischemia and reperfusion than found in controls

• 72% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls

homeostasis/metabolism

increased myocardial infarct size ( J:70292 )

• 120% more necrosis after experimental ischemia and reperfusion than found in controls

• 72% more polymorphonuclear neutrophiles per unit area in mid-ventricular slices relative to controls

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Tg(RHO-VEGFA)V-6Camp/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal angiogenesis ( J:106207 )

• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos2^tm1Lau neovascularization of the retina is significantly reduced

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:112919 , J:143551 )

• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)

• deposits are observed by 52 weeks of age (J:143551)

• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

abnormal hippocampus CA3 region morphology ( J:143551 )

• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

loss of hippocampal neurons ( J:143551 )

• neuronal loss in hippocampus, subiculum and CA3 is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

abnormal subiculum morphology ( J:143551 )

• neuronal loss in subiculum is significantly greater in double mutant relative to control transgenic Tg(APPSWE)2576Kha

decreased neuron number ( J:143551 )

neuron degeneration ( J:112919 )

• widespread cortical neuron damage

behavior/neurological

abnormal long-term spatial reference memory ( J:143551 )

• higher level of errors in day 2 of radial arm water maze in double mutant relative to single mutants Tg(APPSWE)2576Kha or homozygous Nos^tm1Lau

homeostasis/metabolism

amyloid beta deposits ( J:112919 , J:143551 )

• plaque levels elevated in the brain relative to control mice carrying the transgene only (J:112919)

• deposits are observed by 52 weeks of age (J:143551)

• double mutant exhibits increased (3172 pg/ml v. 662 pg/ml) total deposits relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

• ratio of Abeta40:Abeta42 in double mutant is increased (3.8 : 1.5) relative to control transgenic Tg(APPSWE)2576Kha (J:143551)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:112919

Allelic Composition	Nos2^tm1Lau/Nos2^tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2^tm1Lau mutation (8 available); any Nos2 mutation (66 available)
Tg(Thy1-APPSwDutIowa)BWevn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:132221 )

amyloid beta deposits ( J:132221 , J:143551 )

• amyloid beta deposits in the hippocampus, in the subiculum and thalamus (J:132221)

• deposits are observed by 52 weeks of age (J:143551)

abnormal brain interneuron morphology ( J:143551 )

• 65% loss of NPY interneurons in the hippocampus

abnormal hippocampus CA3 region morphology ( J:132221 , J:143551 )

• thinning of the CA3 and subiculum, with a 40% loss of neurons in the CA3 region (J:132221)

• neuronal loss (J:143551)

decreased subiculum size ( J:132221 , J:143551 )

• 35% loss of neurons in the subiculum (J:132221)

• neuronal loss (J:143551)

tau protein deposits ( J:132221 )

• mice show intraneuronal aggregrates of tau

• hyperphosphorylated tau is seen in the brain and in neuronal processes associated with blood vessels

decreased neuron number ( J:143551 )

• neuronal loss is observed in hippocampus, subiculum and CA3

neurodegeneration ( J:132221 )

• 30% loss of NeuN-immunopositive neurons in the hippocampus, 35% loss in the subiculum, and 40% loss in the CA3 region of the hippocampus

• loss of neuropeptide Y-immunopositive neurons particularly in the CA3 region and in the subiculum

hippocampal neuron degeneration ( J:132221 )

• 30% loss of neurons in the hippocampus

• 50% reduction in neuropeptide Y-immunopositive neurons overall throughout the hippocampus, a 65% reduction in the CA3 region, and 50% reduction in the subiculum

homeostasis/metabolism

amyloid beta deposits ( J:132221 , J:143551 )

• amyloid beta deposits in the hippocampus, in the subiculum and thalamus (J:132221)

• deposits are observed by 52 weeks of age (J:143551)

behavior/neurological

abnormal spatial reference memory ( J:132221 )

• mice make more errors in the radial-arm water maze than single Tg(Thy1-APPSwDutIowa)BWevn transgenics, especially on subsequent days, indicating slowed learning and/or retrieval of the task

• mice show increased impaired performance on the Barnes maze compared to single Tg(Thy1-APPSwDutIowa)BWevn transgenics

cellular

increased neuron apoptosis ( J:132221 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:132221

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