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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
ArTfm
testicular feminization
MGI:1856319
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Amhtm1Bhr/Amhtm1Bhr
ArTfm/Y
either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) MGI:2450394
cx2
ArTfmEdaTa-25H/Y involves: 101/H * C3H/HeH MGI:4430366
cx3
ArTfm/Ar+
EdaTa-25H/Eda+
involves: 101/H * C3H/HeH MGI:4459540
cx4
ArTfm/Y
Insl3tm1Imad/Insl3tm1Imad
involves: 129/Sv * CD-1 * STOCK EdaTa MGI:2662011
cx5
ArTfm/Ar+
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
involves: FVB/NJ MGI:3795905
cx6
ArTfm/Y
Tg(TSPY)9Jshm/0
involves: NMRI * STOCK EdaTa Atp7aMo-blo MGI:3815198
ot7
ArTfm/Y involves: NMRI * STOCK EdaTa Atp7aMo-blo MGI:3815199
ot8
ArTfm/Y involves: STOCK EdaTa Atp7aMo-blo MGI:2674328
ot9
ArTfm/Y Not Specified MGI:2665799
ot10
ArTfm/Y STOCK EdaTa Atp7aMo-blo/+ + MGI:2665793


Genotype
MGI:2450394
cx1
Allelic
Composition
Amhtm1Bhr/Amhtm1Bhr
ArTfm/Y
Genetic
Background
either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhtm1Bhr mutation (2 available); any Amh mutation (13 available)
ArTfm mutation (2 available); any Ar mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• absence of vas deferens
• XY male mice developed undescended dysfunctional testes, uteri, coiled oviducts, and a vagina with an opening

endocrine/exocrine glands




Genotype
MGI:4430366
cx2
Allelic
Composition
ArTfmEdaTa-25H/Y
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
EdaTa-25H mutation (1 available); any Eda mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• often small with a runted appearance

pigmentation
• this class is underrepresented at weaning
• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation

reproductive system
• mutant mice are externally female but have abdominally located testes

nervous system
• detected in some mice during fetal development

integument
• this class is underrepresented at weaning
• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation
• Background Sensitivity: transverse black banding characterizes the appearance of this mouse on an agouti background




Genotype
MGI:4459540
cx3
Allelic
Composition
ArTfm/Ar+
EdaTa-25H/Eda+
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
EdaTa-25H mutation (1 available); any Eda mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

pigmentation
• mice of this genotype appear to have black stripes
• this class is underrepresented at weaning
• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation

growth/size/body
• frequently small and runted

craniofacial
• shortened with lateral distortion

skeleton
• shortened with lateral distortion

limbs/digits/tail
• occasionally indications in the region of the hallux of the rear feet
• involving predominantly digits 1 and 2 of both or either front or rear feet

nervous system
• detected in some mice during fetal development

integument
• mice of this genotype appear to have black stripes
• this class is underrepresented at weaning
• Background Sensitivity: black transverse markings are seen, variable in extent and location due to X-inactivation
• Background Sensitivity: transverse black banding characterizes the appearance of this mouse on an agouti background




Genotype
MGI:2662011
cx4
Allelic
Composition
ArTfm/Y
Insl3tm1Imad/Insl3tm1Imad
Genetic
Background
involves: 129/Sv * CD-1 * STOCK EdaTa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
Insl3tm1Imad mutation (0 available); any Insl3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Mullerian duct derivatives were absent
• there is no tight attachment of the testes to the inguinal region
• bilateral cryptorchism with testes situated adjacent to the kidneys
• lack of tight attachment to the inguinal region
• testes were attached to the dorsal abdominal wall by well developed cranial suspsensory ligaments
• the epididymis was absent
• the vas deferens was absent
• the male external and internal genitalia are not virilized

endocrine/exocrine glands
• bilateral cryptorchism with testes situated adjacent to the kidneys
• lack of tight attachment to the inguinal region
• testes were attached to the dorsal abdominal wall by well developed cranial suspsensory ligaments

skeleton
• there is no tight attachment of the testes to the inguinal region

Mouse Models of Human Disease
OMIM ID Ref(s)
Cryptorchidism, Unilateral or Bilateral 219050 J:83429




Genotype
MGI:3795905
cx5
Allelic
Composition
ArTfm/Ar+
Lactb2Tg(Igh-Meis1)2770Amb/Lactb2Tg(Igh-Meis1)2770Amb
Genetic
Background
involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
Lactb2Tg(Igh-Meis1)2770Amb mutation (0 available); any Lactb2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive at least 200 days unlike Lactb2Tg(Igh-Meis1)2770Amb homozygotes




Genotype
MGI:3815198
cx6
Allelic
Composition
ArTfm/Y
Tg(TSPY)9Jshm/0
Genetic
Background
involves: NMRI * STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
Tg(TSPY)9Jshm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

neoplasm
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

endocrine/exocrine glands
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background
• however, no germ cell tumors are observed
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803




Genotype
MGI:3815199
ot7
Allelic
Composition
ArTfm/Y
Genetic
Background
involves: NMRI * STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Background Sensitivity: mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• Background Sensitivity: unlike ArTfm male mice on the original stock background
• Background Sensitivity: in 15 of 46 mice unlike ArTfm male mice on the original stock background
• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

neoplasm
• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

endocrine/exocrine glands
• Background Sensitivity: mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• Background Sensitivity: unlike ArTfm male mice on the original stock background
• Background Sensitivity: in 15 of 46 mice unlike ArTfm male mice on the original stock background
• Background Sensitivity: 4 of 46 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803




Genotype
MGI:2674328
ot8
Allelic
Composition
ArTfm/Y
Genetic
Background
involves: STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

endocrine/exocrine glands
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background

hematopoietic system
• the percentage of TER119+ cells in the bone marrow is decreased
• however, the number of circulating TER119+ cells is not significantly different from controls
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• the percentage of TER119+ cells in the bone marrow is decreased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls

immune system
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803




Genotype
MGI:2665799
ot9
Allelic
Composition
ArTfm/Y
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
• peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
• collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
• at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum
• germ cell development progressed to spermatocytes

nervous system
• mammary glands of male mice are innervated as in female mice

endocrine/exocrine glands
• an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
• peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
• collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
• at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum




Genotype
MGI:2665793
ot10
Allelic
Composition
ArTfm/Y
Genetic
Background
STOCK EdaTa Atp7aMo-blo/+ +
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (2 available); any Ar mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• indistinguishable from females
• XY mice had vaginas that remained closed in most mice, though some did open at 3 months of age
• most spermatocytes were arrested at meiotic prophase, though some were observed in metaphase
• hypertrophic
• testes were positioned amongst fat in the abdomen
• the epididymides were absent from XY mice
• the vas deferens were absent from XY mice
• XY mice possessed testes and female secondary structures including vagina and teats
• XY mice did not possess ovaries

behavior/neurological
• XY mice behaved like non-oestrus females, reduced aggression

digestive/alimentary system
• indistinguishable from females

endocrine/exocrine glands
• hypertrophic
• testes were positioned amongst fat in the abdomen

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:5173





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory