• albino coat (J:27522)

• nitisinone treatment has no effect on pigmentation (J:178454)

• total iris albinism (J:141035)

• absence of pigment in melanosomes

• forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants

• total iris albinism (J:141035)

• had mild focal angle developmental defects, whereas pigmented mice had no observed defects

• increased surface area of temporal retina, as well as additional sectors during E11-13

• increased total number of cells in temporal retina during E11-13

• sustained, early production of ipsilateral retinal ganglion cells up to E14

• Background Sensitivity: mean synaptic ribbon length is decreased in comparison to C57BL/6J

• increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels

• beginning at E11 through E16, cells exhibit smaller size and abnormal packing and organization

• resistant to light damage as compared to albino BALB/cByJ

• reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram

• increased pressure as compared to pigmented C57BL/6J

• dark-adapted threshold s are elevated (decreased sensitivity) in comparison to C57BL/6J

• Background Sensitivity: mean synaptic ribbon length is decreased in comparison to C57BL/6J

• increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels

• mice show dose-dependent DNA lesion formation (cyclobutane dimers) from UV-B exposure, but wild-type or forskolin-treated Mc1r^e mutants show little damage

• forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants

• albino coat (J:27522)

• nitisinone treatment has no effect on pigmentation (J:178454)

• mice lack pigmentation in the skin and eyes

• mice lack detectable amounts of melanin in the hairbulbs

• mice lack pigmentation in the skin and eyes

• mice lack detectable amounts of melanin in the hairbulbs

• following L. monocytogenes infection

• following L. monocytogenes infection

• following L. monocytogenes infection, mice exhibit decreased circulating interferon-alpha and -beta and decreased bacterial numbers in the spleen and liver compared with wild-type mice

• following L. monocytogenes infection

• following L. monocytogenes infection

• mice exhibit normal response to L. monocytogenes infection (J:172226)

• L-dopa administered via pregnant mother throughout ocular development prevents the severe angle dysgenesis

• Background Sensitivity: albino Tyr^c-2J homozygous mice have severe and more extensive angle developmental defects than pigmented Cyp1b1^tm1Gonz/Cyp1b1^tm1Gonz mice

• a small or absent Schlemm's canal

• basal lamina extends from the cornea over the trabecular meshwork

• attachments of the iris to the trabecular meshwork and peripheral cornea

• albino mice had severe and more extensive angle developmental defects than pigmented Foxc1^tm1Blh /Foxc1⁺ mice

• a small or absent Schlemm's canal

• basal lamina extending from the cornea over the trabecular meshwork

• broad synechiae occupies the region where the trabecular meshwork is normally located

• triple mutants do not develop iris disease as seen in double Gpnmb^R150X and Tyrp1^bmice (J:128215)

• at 3 to 4 months, retinyl ester accumulation is 70% of the accumulation observed in Rpe65^tm1Tmr homozygotes

• mice exhibit normal response to L. monocytogenes infection (J:172226)