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Gli1 Gene Detail
Summary
  • Symbol
    Gli1
  • Name
    GLI-Kruppel family member GLI1
  • Synonyms
    Zfp5, Zfp-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95727
    NCBI Gene: 14632
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127165751-127177448 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95727
 protein coding gene Chr10:127165751-127177843 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017819
 protein coding gene Chr10:130921980-130935087 (-)
A/J MGP_AJ_G0017794
 protein coding gene Chr10:125684210-125695918 (-)
AKR/J MGP_AKRJ_G0017757
 protein coding gene Chr10:129393997-129407882 (-)
BALB/cJ MGP_BALBcJ_G0017758
 protein coding gene Chr10:126089364-126101666 (-)
C3H/HeJ MGP_C3HHeJ_G0017582
 protein coding gene Chr10:129546816-129558428 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018213
 protein coding gene Chr10:135357971-135369716 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015893
 protein coding gene Chr10:119682022-119693822 (-)
CAST/EiJ MGP_CASTEiJ_G0017142
 protein coding gene Chr10:130203000-130214684 (-)
CBA/J MGP_CBAJ_G0017551
 protein coding gene Chr10:140813705-140827804 (-)
DBA/2J MGP_DBA2J_G0017657
 protein coding gene Chr10:124767910-124779611 (-)
FVB/NJ MGP_FVBNJ_G0017652
 protein coding gene Chr10:123710618-123722322 (-)
LP/J MGP_LPJ_G0017731
 protein coding gene Chr10:131495821-131508035 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017680
 protein coding gene Chr10:143514276-143526118 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018253
 protein coding gene Chr10:129457766-129470877 (-)
PWK/PhJ MGP_PWKPhJ_G0016927
 protein coding gene Chr10:124972188-124983856 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016719
 protein coding gene Chr10:128498109-128509857 (-)
WSB/EiJ MGP_WSBEiJ_G0017203
 protein coding gene Chr10:129691613-129703349 (-)



Homology
more
  • Human Ortholog
    GLI1, GLI family zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLI1, GLI family zinc finger 1
  • Synonyms
    GLI, PAPA8, PPD1
  • Links
    NCBI Gene ID: 2735
    neXtProt AC: NX_P08151
    UniProt: P08151

  • Chr Location
    12q13.3; chr12:57459785-57472268 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GLI1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    54 phenotypes from multigenic genotypes
    311 phenotype references
Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2259
  • Tissues
    599
  • cDNA Data
    26
  • Literature Summary
    787
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14632 NCBI Gene Model | MGI Sequence Detail 11698 C57BL/6J ±  kb
transcript NM_010296 RefSeq | MGI Sequence Detail 3662 ZRU/MplStud  
polypeptide P47806 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    Genomic 2
    cDNA 33
    Primer pair 43
    Other 69

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10105, MGD-MRK-15893, MGD-MRK-15948, MGI:2143787, MGI:99196
References
more
  • Summaries
    All 1114
    Developmental Gene Expression 787
    Gene Ontology 31
    Phenotypes 311
  • Earliest
    J:5123 Johnson DR, Brachyphalangy, an allele of extra-toes in the mouse. Genet Res. 1969 Jun;13(3):275-80
  • Latest
    J:346597 Seo S, et al., Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):30
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory