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Aqp12 Gene Detail
Summary
  • Symbol
    Aqp12
  • Name
    aquaporin 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664636
    NCBI Gene: 208760
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:92934056-92939991 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664636
 protein coding gene Chr1:92934056-92939991 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016332
 protein coding gene Chr1:94612793-94618779 (+)
A/J MGP_AJ_G0016313
 protein coding gene Chr1:91224907-91231591 (+)
AKR/J MGP_AKRJ_G0016274
 protein coding gene Chr1:93913058-93918938 (+)
BALB/cJ MGP_BALBcJ_G0016269
 protein coding gene Chr1:91398459-91410284 (+)
C3H/HeJ MGP_C3HHeJ_G0016098
 protein coding gene Chr1:94166619-94173763 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016728
 protein coding gene Chr1:98206028-98213251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014446
 protein coding gene Chr1:85475850-85481656 (+)
CAST/EiJ MGP_CASTEiJ_G0015681
 protein coding gene Chr1:93495635-93505637 (+)
CBA/J MGP_CBAJ_G0016072
 protein coding gene Chr1:101399181-101406717 (+)
DBA/2J MGP_DBA2J_G0016177
 protein coding gene Chr1:90420665-90430097 (+)
FVB/NJ MGP_FVBNJ_G0016176
 protein coding gene Chr1:89488109-89494677 (+)
LP/J MGP_LPJ_G0016248
 protein coding gene Chr1:95795584-95803022 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016201
 protein coding gene Chr1:104518141-104527897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016767
 protein coding gene Chr1:93939992-93947142 (+)
PWK/PhJ MGP_PWKPhJ_G0015466
 protein coding gene Chr1:89854215-89860668 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015250
 protein coding gene Chr1:92875585-92881285 (+)
WSB/EiJ MGP_WSBEiJ_G0015741
 protein coding gene Chr1:93750192-93756219 (+)



Homology
more
  • Human Ortholog
    AQP12A, aquaporin 12A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AQP12A, aquaporin 12A
  • Synonyms
    AQP12, AQP-12, AQPX2
  • Links
    NCBI Gene ID: 375318
    neXtProt AC: NX_Q8IXF9
    UniProt: Q8IXF9

  • Chr Location
    2q37.3; chr2:240691866-240698483 (+)  GRCh38
  • Human Ortholog
    AQP12B, aquaporin 12B
  • Synonyms
    INSSA3
  • Links
    NCBI Gene ID: 653437
    neXtProt AC: NX_A6NM10
    UniProt: A6NM10

  • Chr Location
    2q37.3; chr2:240676418-240683810 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice deficient for this marker have elevated total cholesterol levels and show an increased susceptibility to caerulein induced acute pancreatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    13
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208760 NCBI Gene Model | MGI Sequence Detail 5936 C57BL/6J ±  kb
    transcript NM_177587 RefSeq | MGI Sequence Detail 1088 C57BL/6  
    polypeptide Q8CHJ2 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:310854 Okada N, et al., Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells. Biomed Res Int. 2021;2021:6888494
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory