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Sncg Gene Detail
Summary
  • Symbol
    Sncg
  • Name
    synuclein, gamma
  • Synonyms
    C79089, persyn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298397
    NCBI Gene: 20618
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34092231-34096626 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.81 cM, cytoband B-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298397
 protein coding gene Chr14:34092231-34096746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021173
 protein coding gene Chr14:27728510-27733023 (-)
A/J MGP_AJ_G0021121
 protein coding gene Chr14:26655880-26660395 (-)
AKR/J MGP_AKRJ_G0021098
 protein coding gene Chr14:27832419-27836934 (-)
BALB/cJ MGP_BALBcJ_G0021125
 protein coding gene Chr14:26836074-26840589 (-)
C3H/HeJ MGP_C3HHeJ_G0020908
 protein coding gene Chr14:27753744-27758259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021557
 protein coding gene Chr14:28783217-28787732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019119
 protein coding gene Chr14:26677666-26682179 (-)
CAST/EiJ MGP_CASTEiJ_G0020433
 protein coding gene Chr14:27573745-27578226 (-)
CBA/J MGP_CBAJ_G0020875
 protein coding gene Chr14:29837868-29842383 (-)
DBA/2J MGP_DBA2J_G0020997
 protein coding gene Chr14:26690595-26695103 (-)
FVB/NJ MGP_FVBNJ_G0020981
 protein coding gene Chr14:26647317-26651832 (-)
LP/J MGP_LPJ_G0021066
 protein coding gene Chr14:28055007-28059520 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021007
 protein coding gene Chr14:28975302-28979810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021590
 protein coding gene Chr14:27675645-27680145 (-)
PWK/PhJ MGP_PWKPhJ_G0020181
 protein coding gene Chr14:26175341-26179853 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020005
 protein coding gene Chr14:27277066-27281544 (-)
WSB/EiJ MGP_WSBEiJ_G0020488
 protein coding gene Chr14:27725132-27729640 (-)



Homology
more
  • Human Ortholog
    SNCG, synuclein gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNCG, synuclein gamma
  • Synonyms
    BCSG1, SR
  • Links
    NCBI Gene ID: 6623
    neXtProt AC: NX_O76070
    UniProt: O76070

  • Chr Location
    10q23.2; chr10:86955759-86963258 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sncg mouse models; 1 with human SNCG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and show no morphological or functional abnormalities of the nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    73
  • cDNA Data
    43
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20618 NCBI Gene Model | MGI Sequence Detail 4396 C57BL/6J ±  kb
    transcript NM_011430 RefSeq | MGI Sequence Detail 757 ZRU/MplStud  
    polypeptide Q9Z0F7 UniProt | EBI | MGI Sequence Detail 123 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 43
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1353613
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:49830 Buchman VL, et al., Persyn, a member of the synuclein family, influences neurofilament network integrity. Nat Neurosci. 1998 Jun;1(2):101-3
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/23/2024
    MGI 6.23     		The Jackson Laboratory