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Prop1 Gene Detail
Summary
  • Symbol
    Prop1
  • Name
    paired like homeodomain factor 1
  • Synonyms
    Prop-1, prophet of Pit-1, prophet of Pit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109330
    NCBI Gene: 19127
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:50841633-50844584 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.95 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109330
 protein coding gene Chr11:50841633-50844592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018259
 protein coding gene Chr11:50151472-50154431 (-)
A/J MGP_AJ_G0018227
 protein coding gene Chr11:48235145-48238203 (-)
AKR/J MGP_AKRJ_G0018197
 protein coding gene Chr11:49768538-49771497 (-)
BALB/cJ MGP_BALBcJ_G0018197
 protein coding gene Chr11:48529673-48532632 (-)
C3H/HeJ MGP_C3HHeJ_G0018010
 protein coding gene Chr11:49754568-49757527 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018648
 protein coding gene Chr11:51623151-51626110 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016301
 protein coding gene Chr11:45836796-45839853 (-)
CAST/EiJ MGP_CASTEiJ_G0017572
 protein coding gene Chr11:49764628-49767579 (-)
CBA/J MGP_CBAJ_G0017985
 protein coding gene Chr11:54013409-54016368 (-)
DBA/2J MGP_DBA2J_G0018092
 protein coding gene Chr11:48023017-48025973 (-)
FVB/NJ MGP_FVBNJ_G0018086
 protein coding gene Chr11:47659985-47662944 (-)
LP/J MGP_LPJ_G0018167
 protein coding gene Chr11:50524916-50527875 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018111
 protein coding gene Chr11:55513858-55516814 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018692
 protein coding gene Chr11:49861539-49864508 (-)
PWK/PhJ MGP_PWKPhJ_G0017350
 protein coding gene Chr11:48426972-48429921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017145
 protein coding gene Chr11:49583526-49586450 (-)
WSB/EiJ MGP_WSBEiJ_G0017625
 protein coding gene Chr11:49505959-49508908 (-)



Homology
more
  • Human Ortholog
    PROP1, PROP paired-like homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROP1, PROP paired-like homeobox 1
  • Synonyms
    CPHD2, PROP-1
  • Links
    NCBI Gene ID: 5626
    neXtProt AC: NX_O75360
    UniProt: O75360

  • Chr Location
    5q35.3; chr5:177992235-177996242 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prop1 mouse models; 3 with human PROP1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    130 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit severe proportional dwarfism, hypothyroidism, and sterility. Mutants fail to develop the anterior pituitary cells that secrete growth hormone, prolactin, and thyroid stimulating hormone.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    24
  • cDNA Data
    3
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19127 NCBI Gene Model | MGI Sequence Detail 2952 C57BL/6J ±  kb
    transcript NM_008936 RefSeq | MGI Sequence Detail 1125 Not Specified  
    polypeptide P97458 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 15
      cDNA 3
      Primer pair 3
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38375, MGD-MRK-8832
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 46
      Diseases 6
      Gene Ontology 11
      Phenotypes 130
    • Earliest
      J:12169 BARTKE A, HISTOLOGY OF THE ANTERIOR HYPOPHYSIS, THYROID AND GONADS OF TWO TYPES OF DWARF MICE. Anat Rec. 1964 Jun;149:225-35
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory