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Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45111121-45116322 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99702
protein coding gene Chr7:45111121-45116332 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032224
protein coding gene Chr7:45727314-45732515 (-)
A/J MGP_AJ_G0032203
protein coding gene Chr7:44849916-44855117 (-)
AKR/J MGP_AKRJ_G0032139
protein coding gene Chr7:46092173-46097376 (-)
BALB/cJ MGP_BALBcJ_G0032215
protein coding gene Chr7:44837689-44842890 (-)
C3H/HeJ MGP_C3HHeJ_G0031930
protein coding gene Chr7:46577103-46582304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032707
protein coding gene Chr7:47998698-48003901 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029721
protein coding gene Chr7:47396729-47402298 (-)
CAST/EiJ MGP_CASTEiJ_G0031259
protein coding gene Chr7:38001628-38006814 (-)
CBA/J MGP_CBAJ_G0031895
protein coding gene Chr7:49580797-49586000 (-)
DBA/2J MGP_DBA2J_G0032053
protein coding gene Chr7:44512282-44517483 (-)
FVB/NJ MGP_FVBNJ_G0032004
protein coding gene Chr7:44298705-44303908 (-)
LP/J MGP_LPJ_G0032131
protein coding gene Chr7:46424463-46429666 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032041
protein coding gene Chr7:48282764-48287967 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032723
protein coding gene Chr7:45308561-45313764 (-)
PWK/PhJ MGP_PWKPhJ_G0030981
protein coding gene Chr7:37889272-37894484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030819
protein coding gene Chr7:33312581-33317823 (-)
WSB/EiJ MGP_WSBEiJ_G0031376
protein coding gene Chr7:45801041-45807336 (-)



Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    neXtProt AC: NX_Q07812
    UniProt: Q07812

  • Chr Location
    19q13.33; chr19:48954815-48961798 (+)  GRCh38

Human Diseases
more
  • Diseases
    4 with human BAX associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 6 genetic backgrounds
    123 phenotypes from multigenic genotypes
    467 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003873 Ensembl Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
    transcript ENSMUST00000033093 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000033093 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      Genomic 2
      cDNA 50
      Primer pair 16
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16487
    References
    more
    • Summaries
      All 802
      Developmental Gene Expression 149
      Gene Ontology 122
      Phenotypes 467
    • Earliest
      J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
    • Latest
      J:344559 Hughes CHK, et al., Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory