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Ptpn1 Gene Detail
Summary
  • Symbol
    Ptpn1
  • Name
    protein tyrosine phosphatase, non-receptor type 1
  • Synonyms
    PTP-1B, PTP1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97805
    NCBI Gene: 19246
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:167773977-167821305 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.99 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97805
 protein coding gene Chr2:167772670-167821305 (+)
129S1/SvImJ ENSMUSG00200040108
 protein coding gene Chr2:164665331-164712512 (+)
A/J ENSMUSG00195024922
 protein coding gene Chr2:165003709-165050774 (+)
AKR/J ENSMUSG00220030850
 protein coding gene Chr2:164311023-164358086 (+)
BALB/cJ ENSMUSG00180034990
 protein coding gene Chr2:164457316-164504380 (+)
C3H/HeJ ENSMUSG00175036056
 protein coding gene Chr2:165229212-165276270 (+)
C57BL/6NJ ENSMUSG00215022812
 protein coding gene Chr2:164652086-164699146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024713
 protein coding gene Chr2:159857669-159905458 (+)
CAST/EiJ ENSTCUG00005008430
 protein coding gene Chr2:163536513-163583581 (+)
CBA/J ENSMUSG00210035200
 protein coding gene Chr2:165137630-165184697 (+)
DBA/2J ENSMUSG00185023381
 protein coding gene Chr2:164851386-164898457 (+)
FVB/NJ ENSMUSG00205019427
 protein coding gene Chr2:163884087-163931146 (+)
JF1/MsJ ENSUMUG00000028673
 protein coding gene Chr2:164496291-164543400 (+)
LP/J ENSMUSG00230009179
 protein coding gene Chr2:166426119-166473297 (+)
NOD/ShiLtJ ENSMUSG00190034168
 protein coding gene Chr2:164542584-164589645 (+)
NZO/HlLtJ ENSMUSG00225001752
 protein coding gene Chr2:174424289-174471346 (+)
PWK/PhJ ENSLUMG00010033394
 protein coding gene Chr2:164398335-164445012 (+)
SPRET/EiJ ENSMSPG00010024733
 protein coding gene Chr2:167154912-167202063 (+)
WSB/EiJ ENSIUOG00005023686
 protein coding gene Chr2:164254484-164301467 (+)



Homology
more
  • Human Ortholog
    PTPN1, protein tyrosine phosphatase non-receptor type 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN1, protein tyrosine phosphatase non-receptor type 1
  • Synonyms
    PTP1B
  • Links
    NCBI Gene ID: 5770
    UniProt: P18031

  • Chr Location
    20q13.13; chr20:50510321-50585241 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PTPN1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    145 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit greatly reduced adiposity due to reduced fat cell mass, increased basal metabolic rate, mild hypoglycemia and hypoinsulinemia, increased insulin sensitivity, and enhanced sensitivity to leptin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    146
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    14
  • cDNA Data
    129
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027540 Ensembl Gene Model | MGI Sequence Detail 47329 C57BL/6J ±  kb
    transcript ENSMUST00000029053 Ensembl | MGI Sequence Detail 4213 Not Applicable  
    polypeptide ENSMUSP00000029053 Ensembl | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013448 tyrosine-protein phosphatase non-receptor type 1
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR051985 Non-receptor type tyrosine-specific phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P35821 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 1
      cDNA 129
      Primer pair 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13674
    References
    more
    • Summaries
      All 269
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 145
    • Earliest
      J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
    • Latest
      J:390217 Xu D, et al., Microglial PTP1B promotes synaptic pathology and cognitive deficits in chronic Toxoplasma gondii infection. Brain Behav Immun. 2026 Jul 6;:106894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory