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Abcb1b Gene Detail
Summary
  • Symbol
    Abcb1b
  • Name
    ATP-binding cassette, sub-family B member 1B
  • Synonyms
    Abcb1, mdr, Mdr1, Mdr1b, Pgy-1, Pgy1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97568
    NCBI Gene: 18669
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:8848147-8916314 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.43 cM, cytoband A2-A3
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2421 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97568
 protein coding gene Chr5:8848147-8916315 (+)
129S1/SvImJ ENSMUSG00200001966
 protein coding gene Chr5:5545874-5613425 (+)
A/J ENSMUSG00195007439
 protein coding gene Chr5:5556626-5624190 (+)
AKR/J ENSMUSG00220001896
 protein coding gene Chr5:5460380-5527888 (+)
BALB/cJ ENSMUSG00180016165
 protein coding gene Chr5:5308743-5376325 (+)
C3H/HeJ ENSMUSG00175025491
 protein coding gene Chr5:5483975-5551553 (+)
C57BL/6NJ ENSMUSG00215016567
 protein coding gene Chr5:5765563-5833146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026960
 protein coding gene Chr5:5282976-5443694 (+)
CAST/EiJ ENSTCUG00005001387
 protein coding gene Chr5:5650276-5717810 (+)
CBA/J ENSMUSG00210002576
 protein coding gene Chr5:5850194-5917766 (+)
DBA/2J ENSMUSG00185028142
 protein coding gene Chr5:5852361-5919927 (+)
FVB/NJ ENSMUSG00205007234
 protein coding gene Chr5:5559701-5627291 (+)
JF1/MsJ ENSUMUG00000002065
 protein coding gene Chr5:5889459-5961587 (+)
LP/J ENSMUSG00230002775
 protein coding gene Chr5:9803339-9870874 (+)
NOD/ShiLtJ ENSMUSG00190011826
 protein coding gene Chr5:5367515-5439611 (+)
NZO/HlLtJ ENSMUSG00225008500
 protein coding gene Chr5:13538725-13606272 (+)
PWK/PhJ ENSLUMG00010018670
 protein coding gene Chr5:5785773-5853265 (+)
SPRET/EiJ ENSMSPG00010004764
 protein coding gene Chr5:5511233-5774719 (+)
WSB/EiJ ENSIUOG00005022842
 protein coding gene Chr5:5565582-5633120 (+)



Homology
more
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Synonyms
    ABC20, CD243, CLCS, ENPAT, GP170, MDR1, p-170, P-GP, PGY1
  • Links
    NCBI Gene ID: 5243
    UniProt: P08183

  • Chr Location
    7q21.12; chr7:87503017-87713375 (-)  GRCh38
Human Diseases
more
  • Diseases
    28 with human ABCB1 associations

Human Disease Mouse Models
      
IDs
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 View 1 model
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are hypersensitive to effects of drugs transported by phosphoglycoproteins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    82
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    138
  • cDNA Data
    18
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18669 NCBI Gene Model | MGI Sequence Detail 68168 C57BL/6J ±  kb
transcript NM_011075 RefSeq | MGI Sequence Detail 4344 ZRU/MplStud  
polypeptide P06795 UniProt | EBI | MGI Sequence Detail 1276 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000033662 ATP-dependent translocase ABCB1b
    (term hierarchy)
  • EC
    7.6.2.1, 7.6.2.2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003439 ABC transporter-like, ATP-binding domain
    IPR017871 ABC transporter-like, conserved site
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR036640 ABC transporter type 1, transmembrane domain superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR039421 Type 1 protein exporter
  • GlyGen
    P06795 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 50
    Genomic 16
    cDNA 30
    Primer pair 3
    Other 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12177, MGD-MRK-13283, MGD-MRK-13286
References
more
  • Summaries
    All 228
    Developmental Gene Expression 14
    Gene Ontology 23
    Phenotypes 86
  • Earliest
    J:8147 Gros P, et al., Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan;83(2):337-41
  • Latest
    J:390615 Yang L, et al., PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration. Nat Commun. 2026 Jun 12;17(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory