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Pax7 Gene Detail
Summary
  • Symbol
    Pax7
  • Name
    paired box 7
  • Synonyms
    Pax-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:97491
    NCBI Gene: 18509
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139464373-139560839 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.83 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    956 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97491
 protein coding gene Chr4:139464357-139560841 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029023
 protein coding gene Chr4:142589097-142697083 (-)
A/J MGP_AJ_G0028982
 protein coding gene Chr4:136460751-136560161 (-)
AKR/J MGP_AKRJ_G0028934
 protein coding gene Chr4:140374569-140486791 (-)
BALB/cJ MGP_BALBcJ_G0029006
 protein coding gene Chr4:137141342-137249182 (-)
C3H/HeJ MGP_C3HHeJ_G0028720
 protein coding gene Chr4:140763051-140880677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029447
 protein coding gene Chr4:147646669-147761342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026718
 protein coding gene Chr4:129414171-129514578 (-)
CAST/EiJ MGP_CASTEiJ_G0028152
 protein coding gene Chr4:138937620-139079585 (-)
CBA/J MGP_CBAJ_G0028684
 protein coding gene Chr4:151881697-151981338 (-)
DBA/2J MGP_DBA2J_G0028834
 protein coding gene Chr4:136862720-136966668 (-)
FVB/NJ MGP_FVBNJ_G0028801
 protein coding gene Chr4:135900725-136011686 (-)
LP/J MGP_LPJ_G0028933
 protein coding gene Chr4:142673835-142770636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028827
 protein coding gene Chr4:155784812-155892711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029485
 protein coding gene Chr4:140901897-141006853 (-)
PWK/PhJ MGP_PWKPhJ_G0027873
 protein coding gene Chr4:133712153-133816693 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027698
 protein coding gene Chr4:136692138-136793892 (-)
WSB/EiJ MGP_WSBEiJ_G0028230
 protein coding gene Chr4:141173858-141280649 (-)



Homology
more
  • Human Ortholog
    PAX7, paired box 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAX7, paired box 7
  • Synonyms
    CMYP19, HUP1, MYOSCO, PAX7B, RMS2
  • Links
    NCBI Gene ID: 5081
    neXtProt AC: NX_P23759
    UniProt: P23759

  • Chr Location
    1p36.13; chr1:18630846-18748866 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PAX7 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 9 alleles in 12 genetic backgrounds
    51 phenotypes from multigenic genotypes
    4 images
    332 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit craniofacial malformations involving the nose and maxilla, and die within three weeks after birth. Mice homozygous for floxed alleles activated in muscle cells exhibit reduced satellite cell numbers and impaired muscle regeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1611
  • Tissues
    342
  • cDNA Data
    27
  • Literature Summary
    397
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028736 Ensembl Gene Model | MGI Sequence Detail 96467 C57BL/6J ±  kb
    transcript ENSMUST00000174681 Ensembl | MGI Sequence Detail 1725 Not Applicable  
    polypeptide ENSMUSP00000133536 Ensembl | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 2
      cDNA 27
      Primer pair 15
      Other 11

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-13150, MGD-MRK-13159
    References
    more
    • Summaries
      All 755
      Developmental Gene Expression 397
      Gene Ontology 15
      Phenotypes 332
    • Earliest
      J:11250 Jostes B, et al., The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990 Dec;33(1):27-37
    • Latest
      J:345717 Triolo M, et al., Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1. iScience. 2024 Mar 15;27(3):109164
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory