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Oprk1 Gene Detail
Summary
  • Symbol
    Oprk1
  • Name
    opioid receptor, kappa 1
  • Synonyms
    KOR-1, Oprk2, R21
Location &
Maps
more
  • Sequence Map
    Chr1:5658689-5676354 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.89 cM, cytoband A2-A3
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    448 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97439
 protein coding gene Chr1:5658673-5676357 (+)
129S1/SvImJ ENSMUSG00200002635
 protein coding gene Chr1:3051963-3069672 (+)
A/J ENSMUSG00195002792
 protein coding gene Chr1:2866213-2883931 (+)
AKR/J ENSMUSG00220002883
 protein coding gene Chr1:2926423-2944127 (+)
BALB/cJ ENSMUSG00180009028
 protein coding gene Chr1:2943587-2961305 (+)
C3H/HeJ ENSMUSG00175000289
 protein coding gene Chr1:2805000-2822756 (+)
C57BL/6NJ ENSMUSG00215003901
 protein coding gene Chr1:2849212-2866923 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013928
 protein coding gene Chr1:2288764-2304484 (+)
CAST/EiJ ENSTCUG00005002038
 protein coding gene Chr1:3196496-3214206 (+)
CBA/J ENSMUSG00210001698
 protein coding gene Chr1:2728904-2746662 (+)
DBA/2J ENSMUSG00185004413
 protein coding gene Chr1:3772730-3790483 (+)
FVB/NJ ENSMUSG00205005142
 protein coding gene Chr1:3005636-3023361 (+)
JF1/MsJ ENSUMUG00000002479
 protein coding gene Chr1:3031532-3049263 (+)
LP/J ENSMUSG00230001699
 protein coding gene Chr1:3755936-3773639 (+)
NOD/ShiLtJ ENSMUSG00190001111
 protein coding gene Chr1:2873168-2890875 (+)
NZO/HlLtJ ENSMUSG00225000126
 protein coding gene Chr1:7140920-7158640 (+)
PWK/PhJ ENSLUMG00010002214
 protein coding gene Chr1:2622309-2640082 (+)
SPRET/EiJ ENSMSPG00010013642
 protein coding gene Chr1:3173051-3190838 (+)
WSB/EiJ ENSIUOG00005010796
 protein coding gene Chr1:2843982-2861712 (+)



Homology
more
  • Human Ortholog
    OPRK1, opioid receptor kappa 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPRK1, opioid receptor kappa 1
  • Synonyms
    KOP, KOR, K-OR-1, KOR-1, KOR1, OPRK
  • Links
    NCBI Gene ID: 4986
    UniProt: P41145

  • Chr Location
    8q11.23; chr8:53225724-53251637 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human OPRK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 5 alleles in 9 genetic backgrounds
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired response to morphine and an opioid agonist, abnormal pain threshold, and increased litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    130
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025905 Ensembl Gene Model | MGI Sequence Detail 17666 C57BL/6J ±  kb
    transcript ENSMUST00000239100 Ensembl | MGI Sequence Detail 4675 Not Applicable  
    polypeptide ENSMUSP00000158863 Ensembl | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 5
      cDNA 18
      Primer pair 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13039, MGD-MRK-16304, MGI:99527
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 85
    • Earliest
      J:13204 Yasuda K, et al., Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40
    • Latest
      J:375447 Neiswanger C, et al., G Protein Inactivation as a Mechanism for Addiction Treatment. Biol Psychiatry. 2026 Jan 1;99(1):80-90
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory