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Itgb6 Gene Detail
Summary
  • Symbol
    Itgb6
  • Name
    integrin beta 6
  • Synonyms
    2210409C20Rik, 4831415H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96615
    NCBI Gene: 16420
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:60428636-60552987 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 34.81 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3369 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96615
 protein coding gene Chr2:60428636-60553005 (-)
129S1/SvImJ ENSMUSG00200002603
 protein coding gene Chr2:57497912-57621861 (-)
A/J ENSMUSG00195004844
 protein coding gene Chr2:57615950-57740646 (-)
AKR/J ENSMUSG00220007275
 protein coding gene Chr2:57718085-57842455 (-)
BALB/cJ ENSMUSG00180019667
 protein coding gene Chr2:57572148-57696506 (-)
C3H/HeJ ENSMUSG00175012472
 protein coding gene Chr2:57640964-57765337 (-)
C57BL/6NJ ENSMUSG00215007456
 protein coding gene Chr2:57625644-57749992 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023585
 protein coding gene Chr2:55438489-55563034 (-)
CAST/EiJ ENSTCUG00005022137
 protein coding gene Chr2:56979143-57100967 (-)
CBA/J ENSMUSG00210033191
 protein coding gene Chr2:57660114-57784463 (-)
DBA/2J ENSMUSG00185007565
 protein coding gene Chr2:57516430-57640326 (-)
FVB/NJ ENSMUSG00205015561
 protein coding gene Chr2:57156830-57281182 (-)
JF1/MsJ ENSUMUG00000016796
 protein coding gene Chr2:57215279-57334685 (-)
LP/J ENSMUSG00230001358
 protein coding gene Chr2:59381599-59505527 (-)
NOD/ShiLtJ ENSMUSG00190027377
 protein coding gene Chr2:57605269-57729638 (-)
NZO/HlLtJ ENSMUSG00225000724
 protein coding gene Chr2:67104735-67229075 (-)
PWK/PhJ ENSLUMG00010005412
 protein coding gene Chr2:57380629-57506449 (-)
SPRET/EiJ ENSMSPG00010011584
 protein coding gene Chr2:58532708-58657468 (-)
WSB/EiJ ENSIUOG00005027882
 protein coding gene Chr2:57642989-57766824 (-)



Homology
more
  • Human Ortholog
    ITGB6, integrin subunit beta 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB6, integrin subunit beta 6
  • Synonyms
    AI1H
  • Links
    NCBI Gene ID: 3694
    UniProt: P18564

  • Chr Location
    2q24.2; chr2:160099664-160271888 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Itgb6 mouse models; 1 with human ITGB6 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    3 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit baldness associated with macrophage infiltration of skin, exaggerated pulmonary inflammation, and an impaired mucosal mast cell response to nematode infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026971 Ensembl Gene Model | MGI Sequence Detail 124352 C57BL/6J ±  kb
    transcript ENSMUST00000059888 Ensembl | MGI Sequence Detail 4806 Not Applicable  
    polypeptide ENSMUSP00000054944 Ensembl | MGI Sequence Detail 787 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009142 integrin beta-6
      (term hierarchy)
    • PDB
      8FSO
    • InterPro Domains
      IPR013111 Epidermal growth factor-like domain, extracellular
      IPR040622 Integrin beta, epidermal growth factor-like domain 1
      IPR057073 Integrin beta, epidermal growth factor-like domain 2
      IPR033760 Integrin beta N-terminal
      IPR015812 Integrin beta subunit
      IPR014836 Integrin beta subunit, cytoplasmic domain
      IPR012896 Integrin beta subunit, tail
      IPR002369 Integrin beta subunit, VWA domain
      IPR036349 Integrin beta tail domain superfamily
      IPR032695 Integrin domain superfamily
      IPR057243 Integrins beta, I-EGF domain, conserved site
      IPR016201 PSI domain
      IPR036465 von Willebrand factor A-like domain superfamily
    • GlyGen
      Q9Z0T9 11 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 4
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11494, MGI:1917381, MGI:1925805
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 23
      Phenotypes 51
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:391144 Mizuta K, et al., Nephronectin promotes ameloblast differentiation through its RGD motif. Biochem Biophys Res Commun. 2026 Aug 6;832:154409
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory