About   Help   FAQ
Gna11 Gene Detail
Summary
  • Symbol
    Gna11
  • Name
    guanine nucleotide binding protein, alpha 11
  • Synonyms
    Dsk7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95766
    NCBI Gene: 14672
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81364558-81380996 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95766
 protein coding gene Chr10:81364558-81381024 (-)
129S1/SvImJ ENSMUSG00200042032
 protein coding gene Chr10:77991696-78008165 (-)
A/J ENSMUSG00195044749
 protein coding gene Chr10:78386994-78403464 (-)
AKR/J ENSMUSG00220047980
 protein coding gene Chr10:77984659-78001126 (-)
BALB/cJ ENSMUSG00180051063
 protein coding gene Chr10:78397437-78413901 (-)
C3H/HeJ ENSMUSG00175042644
 protein coding gene Chr10:78268183-78284645 (-)
C57BL/6NJ ENSMUSG00215049753
 protein coding gene Chr10:78010057-78026528 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015647
 protein coding gene Chr10:75531517-75548098 (-)
CAST/EiJ ENSTCUG00005050753
 protein coding gene Chr10:77892235-77908699 (-)
CBA/J ENSMUSG00210037012
 protein coding gene Chr10:78124216-78140680 (-)
DBA/2J ENSMUSG00185048666
 protein coding gene Chr10:78466646-78483113 (-)
FVB/NJ ENSMUSG00205049120
 protein coding gene Chr10:78180489-78196961 (-)
JF1/MsJ ENSUMUG00000029287
 protein coding gene Chr10:79694653-79711524 (-)
LP/J ENSMUSG00230050698
 protein coding gene Chr10:80236204-80252672 (-)
NOD/ShiLtJ ENSMUSG00190031100
 protein coding gene Chr10:78380327-78396793 (-)
NZO/HlLtJ ENSMUSG00225049222
 protein coding gene Chr10:84522778-84539245 (-)
PWK/PhJ ENSLUMG00010045832
 protein coding gene Chr10:78057767-78074609 (-)
SPRET/EiJ ENSMSPG00010033347
 protein coding gene Chr10:79669033-79685738 (-)
WSB/EiJ ENSIUOG00005048759
 protein coding gene Chr10:78120746-78137205 (-)



Homology
more
  • Human Ortholog
    GNA11, G protein subunit alpha 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA11, G protein subunit alpha 11
  • Synonyms
    FBH, FBH2, FHH2, GNA-11, HG1K, HHC2, HYPOC2
  • Links
    NCBI Gene ID: 2767
    UniProt: P29992

  • Chr Location
    19p13.3; chr19:3094362-3123999 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gna11 mouse models; 2 with human GNA11 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 7 genetic backgrounds
    75 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    40
  • cDNA Data
    12
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14672 NCBI Gene Model | MGI Sequence Detail 16439 C57BL/6J ±  kb
    transcript NM_010301 RefSeq | MGI Sequence Detail 3404 ZRU/MplStud  
    polypeptide P21278 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008080 guanine nucleotide-binding protein subunit alpha-11
      (term hierarchy)
    • InterPro Domains
      IPR000654 G-protein alpha subunit, group Q
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein, alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P21278 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 8
      cDNA 12
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10175, MGI:2450689
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 23
      Phenotypes 94
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:391252 Neve V, et al., A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation. Nat Commun. 2026 Jun 20;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory