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Ghrh Gene Detail
Summary
  • Symbol
    Ghrh
  • Name
    growth hormone releasing hormone
  • Synonyms
    Ghrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:95709
    NCBI Gene: 14601
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157171417-157189426 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.25 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95709
protein coding gene Chr2:157171416-157190645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026780
protein coding gene Chr2:162325987-162344045 (-)
A/J MGP_AJ_G0026746
protein coding gene Chr2:155838476-155856932 (-)
AKR/J MGP_AKRJ_G0026717
protein coding gene Chr2:160423439-160443201 (-)
BALB/cJ MGP_BALBcJ_G0026755
protein coding gene Chr2:156129201-156147047 (-)
C3H/HeJ MGP_C3HHeJ_G0026497
protein coding gene Chr2:160737508-160755331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027204
protein coding gene Chr2:167153892-167171629 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024574
protein coding gene Chr2:149292903-149311827 (-)
CAST/EiJ MGP_CASTEiJ_G0025959
protein coding gene Chr2:161075032-161097583 (-)
CBA/J MGP_CBAJ_G0026474
protein coding gene Chr2:173167400-173185211 (-)
DBA/2J MGP_DBA2J_G0026612
protein coding gene Chr2:155016524-155035109 (-)
FVB/NJ MGP_FVBNJ_G0026579
protein coding gene Chr2:153404312-153422648 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0026600
protein coding gene Chr2:177018138-177038177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027260
protein coding gene Chr2:160237363-160255414 (-)
PWK/PhJ MGP_PWKPhJ_G0025693
protein coding gene Chr2:154532153-154551928 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025496
protein coding gene Chr2:159189018-159206883 (-)
WSB/EiJ MGP_WSBEiJ_G0026029
protein coding gene Chr2:161131344-161149870 (-)



Homology
more
  • Human Ortholog
    GHRH, growth hormone releasing hormone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GHRH, growth hormone releasing hormone
  • Synonyms
    GHRF, GRF, INN
  • Links
    NCBI Gene ID: 2691
    neXtProt AC: NX_P01286
    UniProt: P01286

  • Chr Location
    20q11.23; chr20:37251086-37261819 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Ghrh mouse models; 4 with human GHRH associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygoous for a knock-out allele exhibit postnatal growth retardation, decreased body weight and body length, reduced IGF-I production and serum IGF-I levels, pituitary hypoplasia, decreased growth hormone level, and decreased litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027643 Ensembl Gene Model | MGI Sequence Detail 18010 C57BL/6J ±  kb
    transcript ENSMUST00000109536 Ensembl | MGI Sequence Detail 503 Not Applicable  
    polypeptide ENSMUSP00000105162 Ensembl | MGI Sequence Detail 103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10071, MGD-MRK-10073
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 20
      Phenotypes 28
    • Earliest
      J:47391 Mitrakou A, et al., Heterogeneity of growth-hormone deficiency [letter]. Lancet. 1985 Feb 16;1(8425):399-400
    • Latest
      J:342946 Recinella L, et al., Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice. Cells. 2023 Nov 12;12(22)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory