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Arg1 Gene Detail
Summary
  • Symbol
    Arg1
  • Name
    arginase, liver
  • Synonyms
    AI, Arg-1, PGIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:88070
    NCBI Gene: 11846
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24791105-24803368 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88070
 protein coding gene Chr10:24791105-24803382 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017096
 protein coding gene Chr10:22913588-22927899 (-)
A/J MGP_AJ_G0017073
 protein coding gene Chr10:22237155-22248686 (-)
AKR/J MGP_AKRJ_G0017033
 protein coding gene Chr10:22612988-22624540 (-)
BALB/cJ MGP_BALBcJ_G0017036
 protein coding gene Chr10:22335026-22348993 (-)
C3H/HeJ MGP_C3HHeJ_G0016856
 protein coding gene Chr10:22821472-22833279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017494
 protein coding gene Chr10:23618173-23632185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015192
 protein coding gene Chr10:20929653-20941461 (-)
CAST/EiJ MGP_CASTEiJ_G0016435
 protein coding gene Chr10:22754079-22767328 (-)
CBA/J MGP_CBAJ_G0016830
 protein coding gene Chr10:24690896-24706317 (-)
DBA/2J MGP_DBA2J_G0016935
 protein coding gene Chr10:21967622-21980085 (-)
FVB/NJ MGP_FVBNJ_G0016930
 protein coding gene Chr10:21667359-21679588 (-)
LP/J MGP_LPJ_G0017012
 protein coding gene Chr10:22906422-22917863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016960
 protein coding gene Chr10:24799816-24812350 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017530
 protein coding gene Chr10:22464342-22477159 (-)
PWK/PhJ MGP_PWKPhJ_G0016217
 protein coding gene Chr10:21754708-21767859 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016001
 protein coding gene Chr10:22301070-22312797 (-)
WSB/EiJ MGP_WSBEiJ_G0016498
 protein coding gene Chr10:22597547-22609077 (-)



Homology
more
  • Human Ortholog
    ARG1, arginase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARG1, arginase 1
  • Links
    NCBI Gene ID: 383
    neXtProt AC: NX_P05089
    UniProt: P05089

  • Chr Location
    6q23.2; chr6:131470832-131584332 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arg1 mouse models; 3 with human ARG1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show postnatal lethality, hyperammonemia, argininemia, altered plasma levels of other amino acids, enlarged pale livers, and abnormal hepatocytes. Mice homozygous for a different null allele show postnatal lethality, andincreased macrophage nitric oxide production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1200
  • Tissues
    318
  • cDNA Data
    167
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11846 NCBI Gene Model | MGI Sequence Detail 12264 C57BL/6J ±  kb
    transcript NM_007482 RefSeq | MGI Sequence Detail 1489 C57BL/6  
    polypeptide Q61176 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 170
      cDNA 167
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1392, MGD-MRK-1393, MGI:2143548
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 9
      Phenotypes 110
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345901 Akinjiyan FA, et al., DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. Oncogene. 2024 Jan;43(3):189-201
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory