Arg1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arg1
arginase, liver
MGI:88070

23 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Arg1^tm1.1Lky/\Arg1^tm1.1Lky involves: 129S4/SvJae * C57BL/6	no abnormal phenotype detected	J:122735
\Arg1^tm1.1Pmu/\Arg1^tm1.1Pmu involves: C57BL/6 * NZB	increased macrophage nitric oxide production	J:143229
\Arg1^tm1.1Pmu/\Arg1^tm1.1Pmu involves: C57BL/6 * NZB	postnatal lethality	J:143229
\Arg1^tm1Ekoe/\Arg1^tm1Ekoe involves: 129P2/OlaHsd	abnormal blood homeostasis	J:183882
\Arg1^tm1Ekoe/\Arg1^tm1Ekoe involves: 129P2/OlaHsd	abnormal macrophage physiology	J:183882
\Arg1^tm1Pmu/\Arg1^tm1Pmu \Lyz2^tm1(cre)Ifo/? B6.Cg-Arg1^tm1Pmu Lyz2^tm1(cre)Ifo	decreased susceptibility to parasitic infection	J:143229
\Arg1^tm1Pmu/\Arg1^tm1Pmu \Tg(Tek-cre)1Ywa/? B6.Cg-Tg(Tek-cre)1Ywa Arg1^tm1Pmu	abnormal macrophage physiology	J:143229
	abnormal nitric oxide homeostasis	J:143229
	decreased susceptibility to bacterial infection	J:143229
	increased macrophage nitric oxide production	J:143229
\Arg1^tm1Rki/\Arg1^tm1Rki Not Specified	abnormal circulating amino acid level	J:83263
	abnormal hepatobiliary system morphology	J:83263
	abnormal hepatocyte morphology	J:83263
	abnormal homeostasis	J:83263
	abnormal liver morphology	J:83263
	decreased circulating ornithine level	J:83263
	decreased circulating proline level	J:83263
	enlarged liver	J:83263
	increased circulating ammonia level	J:83263
	increased circulating arginine level	J:83263
	increased circulating citrulline level	J:83263
	increased circulating histidine level	J:83263
	normal nervous system phenotype	J:83263
	pale liver	J:83263
	postnatal lethality, complete penetrance	J:83263

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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