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Acvr2b Gene Detail
Summary
  • Symbol
    Acvr2b
  • Name
    activin receptor IIB
  • Synonyms
    ActRIIB
  • Feature Type
    protein coding gene
  • IDs
    MGI:87912
    NCBI Gene: 11481
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119231184-119264061 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    815 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87912
 protein coding gene Chr9:119231081-119271214 (+)
129S1/SvImJ ENSMUSG00200027877
 protein coding gene Chr9:116350060-116382943 (+)
A/J ENSMUSG00195026912
 protein coding gene Chr9:115532118-115565137 (+)
AKR/J ENSMUSG00220019173
 protein coding gene Chr9:115989137-116022136 (+)
BALB/cJ ENSMUSG00180029132
 protein coding gene Chr9:116069476-116102491 (+)
C3H/HeJ ENSMUSG00175018615
 protein coding gene Chr9:116312769-116345783 (+)
C57BL/6NJ ENSMUSG00215029041
 protein coding gene Chr9:116183287-116216168 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032801
 protein coding gene Chr9:114821500-114854310 (+)
CAST/EiJ ENSTCUG00005015884
 protein coding gene Chr9:115954835-115987851 (+)
CBA/J ENSMUSG00210039961
 protein coding gene Chr9:116028081-116061083 (+)
DBA/2J ENSMUSG00185015904
 protein coding gene Chr9:116362327-116395329 (+)
FVB/NJ ENSMUSG00205028593
 protein coding gene Chr9:116200967-116233985 (+)
JF1/MsJ ENSUMUG00000024207
 protein coding gene Chr9:116230890-116263881 (+)
LP/J ENSMUSG00230036150
 protein coding gene Chr9:116478426-116511304 (+)
NOD/ShiLtJ ENSMUSG00190013125
 protein coding gene Chr9:115961813-115994693 (+)
NZO/HlLtJ ENSMUSG00225022985
 protein coding gene Chr9:116745025-116777903 (+)
PWK/PhJ ENSLUMG00010032098
 protein coding gene Chr9:116125761-116158746 (+)
SPRET/EiJ ENSMSPG00010019331
 protein coding gene Chr9:117822970-117855894 (+)
WSB/EiJ ENSIUOG00005019961
 protein coding gene Chr9:115414634-115447534 (+)



Homology
more
  • Human Ortholog
    ACVR2B, activin A receptor type 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACVR2B, activin A receptor type 2B
  • Synonyms
    ActR-IIB, ACTRIIB, HTX4
  • Links
    NCBI Gene ID: 93
    UniProt: Q13705

  • Chr Location
    3p22.2; chr3:38453890-38493142 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Acvr2b mouse models; 1 with human ACVR2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 6 genetic backgrounds
    21 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene show abnormal lateral asymmetry and homeotic transformation of the axial skeleton, and die shortly after birth with extensive cardiac defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1074
  • Tissues
    197
  • cDNA Data
    39
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061393 Ensembl Gene Model | MGI Sequence Detail 32878 C57BL/6J ±  kb
    transcript ENSMUST00000165044 Ensembl | MGI Sequence Detail 2093 Not Applicable  
    polypeptide ENSMUSP00000126108 Ensembl | MGI Sequence Detail 536 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 2
      cDNA 40
      Primer pair 9
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1098
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 45
      Diseases 1
      Gene Ontology 33
      Phenotypes 34
    • Earliest
      J:1073 Matzuk MM, et al., Structure of the mouse activin receptor type II gene. Biochem Biophys Res Commun. 1992 May 29;185(1):404-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory