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Acvr2btm1Enl
Targeted Allele Detail
Summary
Symbol: Acvr2btm1Enl
Name: activin receptor IIB; targeted mutation 1, En Li
MGI ID: MGI:1857709
Synonyms: ActRIIB-, Acvr2b-, IIB-KO
Gene: Acvr2b  Location: Chr9:119231184-119264061 bp, + strand  Genetic Position: Chr9, 71.33 cM
Alliance: Acvr2btm1Enl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42018
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.4kb genomic fragment containing two exons encoding the transmembrane and part of the kinase domains was replaced by a neomycin resistance cassette. (J:42018)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 83 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvr2b Mutation:  27 strains or lines available
References
Original:  J:42018 Oh SP, et al., The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 1997 Jul 15;11(14):1812-26
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory