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Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529721
Gene symbol: Tubb3
Gene name: tubulin, beta 3 class III
Antibody: anti-Tuj1
Results
Specimen 2A Tuj1: embryonic day 16.5 (more )
Note: Double labeled: green - Tubb3; red - Smad1 (assay MGI:7529718).
Structure Cell Type Level Pattern Image Note
TS24: dorsal root ganglion sensory neuron of dorsal root ganglion Present 2A , 2A inset
Specimen 2B Tuj1 E15.5: embryonic day 15.5 (more )
Note: Double labeled: green - Tubb3; red - Smad1 (assay MGI:7529718).
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion Trace 2B E15.5 Tuj1 , 2B E15.5 (merged)
TS23: peripheral nerve peripheral sensory neuron Present 2B E15.5 (merged) , 2B E15.5 Tuj1
Specimen 2B Tuj1 P1: postnatal day 1 (more )
Note: Double labeled: green - Tubb3; red - Smad1 (assay MGI:7529718).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present 2B P1 (merged) , 2B P1 Tuj1
TS27: peripheral nerve peripheral sensory neuron Present 2B P1 (merged) , 2B P1 Tuj1
Specimen 3D Tuj1 Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present 3D Tuj1 Control
Specimen 3D Tuj1 cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: thoracic dorsal root ganglion sensory neuron of dorsal root ganglion Present 3D Tuj1 cKO-Nes Total number of neurons comparable to control.
Specimen S3E Tuj1 Control: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present S3E Tuj1 Control Expression in cental axon projections of dorsal root ganglion sensory neurons into spinal cord.
Specimen S3E Tuj1 cKO-Wnt1: postnatal day 1; H2az2Tg(Wnt1-cre)11Rth/0, Smad1tm1Abr/Smad1tm1.1Abr (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: spinal nerve dorsal root sensory neuron of spinal nerve Present S3E Tuj1 cKO-Wnt1 No changes in central branch innervation.
Specimen S6D Tuj1 +/+: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6D Tuj1 +/+
Specimen S6D Tuj1 L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6D Tuj1 L/L No significant difference in total number of neurons.
Specimen S6F Tuj1: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: peripheral nerve peripheral sensory neuron Present S6F Tuj1
Specimen S6G Tuj1: postnatal day 1 (more )
Note: Double labeled: green - Tubb3; red - Smad1 (assay MGI:7529719).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present S6G
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory