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Gene Expression Data
Assay Details
Assay
Reference: J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7529718
Gene symbol: Smad1
Gene name: SMAD family member 1
Antibody: anti-pSmad1C
Results
Specimen 1F Control: postnatal day 1; Smad1tm1Abr/Smad1+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Strong 1F Control Abundant expression in majority of sensory neurons.
Specimen 1F cKO-Nes: postnatal day 1; Smad1tm1Abr/Smad1tm1.1Abr, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: dorsal root ganglion Absent 1F cKO-Nes
Specimen 2A pSmad1C: embryonic day 16.5 (more )
Note: Double labeled: red - Smad1; green - Tubb3 (assay MGI:7529721).
Structure Cell Type Level Pattern Image Note
TS24: dorsal root ganglion sensory neuron of dorsal root ganglion Present 2A , 2A inset Expression specifically expressed in sensory neurons.
TS24: dorsal root ganglion glial cell Absent 2A , 2A inset No expression in glial cells.
Specimen 2B pSmad1C E15.5: embryonic day 15.5 (more )
Note: Double labeled: red - Smad1; green - Tubb3 (assay MGI:7529721).
Structure Cell Type Level Pattern Image Note
TS23: dorsal root ganglion sensory neuron of dorsal root ganglion Present 2B E15.5 pSmad1C , 2B E15.5 (merged) Expression specifically in sensory neurons.
TS23: peripheral nerve Schwann cell Absent 2B E15.5 (merged) , 2B E15.5 pSmad1C No expression in Schwann cells.
Specimen 2B pSmad1C P1: postnatal day 1 (more )
Note: Double labeled: red - Smad1; green - Tubb3 (assay MGI:7529721).
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present 2B P1 (merged) , 2B P1 Smad1C Expression specifically in sensory neurons.
TS27: peripheral nerve Schwann cell Absent 2B P1 (merged) , 2B P1 Smad1C No expression in Schwann cells.
Specimen 6E +/+: postnatal day 1 (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present 6E +/+
Specimen 6E L/L: postnatal day 1; Smad1tm2Sor/Smad1tm2Sor (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion sensory neuron of dorsal root ganglion Present 6E L/L Level of expression comparable to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory