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Gene Expression Data
Assay Details
Assay
Reference: J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6449800
Gene symbol: Myt1
Gene name: myelin transcription factor 1
Antibody: anti-Myt1
Detection system: Cy3
Results
Specimen 1A1 inset: embryonic day 8.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS13: foregut-midgut junction Ambiguous Regionally restricted 1A1 inset No expression in prospective pancreatic epithelium before E8.5.
Specimen 1A1: embryonic day 9.0 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS14: foregut-midgut junction Present Regionally restricted 1A1 Most expressing cells in prospective pancreas also express Pdx1.
Specimen 1A2: embryonic day 10.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1A2 Expression in all insulin-expressing cells.
Specimen 1A3: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1A3 Expression maintained in 91% of insulin-expressing cells.
Specimen 1A4: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ins1 (assay MGI:6449808) and Ins2 (assay MGI:6450025).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1A4 Expression detected in 58.6% of insulin-expressing cells.
Specimen 1B1: embryonic day 9.0 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS14: foregut-midgut junction Present Regionally restricted 1B1 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B2: embryonic day 10.5 (more )
Note: Triple labeled: red - Myt1; blue - Pdx1 (assay MGI:6449807); green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS17: pancreas primordium Present Regionally restricted 1B2 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B3: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1B3 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B4: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1B4 Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1B4 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Gcg (assay MGI:6449809).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1B4 inset Expression in Gct-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied
Specimen 1C1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1C1 Expression in Sst-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1C2: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1C2 Expression in Sst-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1C2 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Ppy (assay MGI:6449810).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 1C2 inset
Specimen 1D1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present Regionally restricted 1D1 Expression in Ppy-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1D2: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 1D2 Expression in Ppy-expressing cells. Percentage co-expressing cells (~95%) remains relatively constant at all stages studied.
Specimen 1D2 inset: postnatal week 12 (more )
Note: Double labeled: red - Myt1; green - Sst (assay MGI:6449811).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 1D2 inset
Specimen 2 E10.5: embryonic day 10.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS17: pancreas primordium Present 2_E10.5 Merge , 2_E10.5 Myt1
Specimen 2 E13.5: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS21: pancreas Present 2_E13.5 Myt1 , 2_E13.5 Merge
Specimen 2 E15.5: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Neurog3 (assay MGI:6449812).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present 2_E15.5 Merge , 2_E15.5 Myt1
Specimen S1 E13.5 Isl1: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Isl1 (assay MGI:6449817).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 Isl1 (bottom) , S1_E13.5 Isl1 (merge) Expression overlaps with expression of Isl1.
Specimen S1 E13.5 MafA: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Mafa (assay MGI:6449813).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 MafA (bottom) , S1_E13.5 MafA (merge) Expression overlaps with expression of Mafa.
Specimen S1 E13.5 MafB: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Mafb (assay MGI:6449814).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 MafB (merge) , S1_E13.5 MafB (bottom) Expression overlaps with expression of Mafb.
Specimen S1 E13.5 Nkx6.1: embryonic day 13.5 (more )
Note: Double labeled: red - Myt1; green - Nkx6-1 (assay MGI:6449819).
Structure Level Pattern Image Note
TS21: pancreas Present Regionally restricted S1_E13.5 Nkx6.1 (bottom) , S1_E13.5 Nkx6.1 (merge) Expression overlaps with expression of Nkx6.1.
Specimen S1 E15.5 Isl1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Isl1 (assay MGI:6449817).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 Isl1 (merge) , S1_E15.5 Isl1 (bottom)
Specimen S1 E15.5 MafA: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Mafa (assay MGI:6449813).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 MafA (merge) , S1_E15.5 MafA (bottom)
Specimen S1 E15.5 MafB: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Mafb (assay MGI:6449814).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 MafB (merge) , S1_E15.5 MafB (bottom)
Specimen S1 E15.5 Nkx6.1: embryonic day 15.5 (more )
Note: Double labeled: red - Myt1; green - Nkx6-1 (assay MGI:6449819).
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S1_E15.5 Nkx6.1 (bottom) , S1_E15.5 Nkx6.1 (merge)
Specimen S5A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: islets of Langerhans Present S5A
Specimen S5B: embryonic day 15.5; Myt1tm1.1Ggu/Myt1tm1.1Ggu (more )
Structure Level Pattern Image Note
TS23: islets of Langerhans Absent S5B
Specimen S5C: embryonic day 15.5; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: islets of Langerhans Weak S5C Expression reduced compared to wild type.
Specimen S5D: embryonic day 18.5; Myt1tm1Ggu/Myt1tm1.1Ggu, Tg(Pdx1-cre)89.1Dam/? (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: islets of Langerhans Absent S5D No expression in pancreatic cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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