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Lrrc7 Gene Detail
Summary
  • Symbol
    Lrrc7
  • Name
    leucine rich repeat containing 7
  • Synonyms
    B230334C09Rik, densin, mKIAA1365
Location &
Maps
more
  • Sequence Map
    Chr3:157772823-158268254 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, Syntenic
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9048 from dbSNP Build 142
  • Strain Annotations
    37
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676665
 protein coding gene Chr3:157772823-158268254 (-)
129S1/SvImJ ENSMUSG00200000062
 protein coding gene Chr3:154789501-155249428 (-)
129S1/SvImJ ENSMUSG00200000161
 lncRNA gene Chr3:154773799-154782730 (-)
A/J ENSMUSG00195002623
 protein coding gene Chr3:154915971-155391777 (-)
A/J ENSMUSG00195002676
 lncRNA gene Chr3:154900275-154909204 (-)
AKR/J ENSMUSG00220011117
 lncRNA gene Chr3:153324431-153333360 (-)
AKR/J ENSMUSG00220011045
 protein coding gene Chr3:153340127-153815807 (-)
BALB/cJ ENSMUSG00180006848
 lncRNA gene Chr3:154751991-154760918 (-)
BALB/cJ ENSMUSG00180006521
 protein coding gene Chr3:154767685-155240633 (-)
C3H/HeJ ENSMUSG00175003435
 lncRNA gene Chr3:154368458-154377387 (-)
C3H/HeJ ENSMUSG00175003289
 protein coding gene Chr3:154384154-154863807 (-)
C57BL/6NJ ENSMUSG00215004325
 protein coding gene Chr3:154995406-155474832 (-)
C57BL/6NJ ENSMUSG00215004448
 lncRNA gene Chr3:154979697-154988623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025769
 protein coding gene Chr3:150940808-151386340 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0003479
 antisense lncRNA gene Chr3:150925229-150934246 (-)
CAST/EiJ ENSTCUG00005000080
 lncRNA gene Chr3:155414868-155424286 (-)
CAST/EiJ ENSTCUG00005000048
 protein coding gene Chr3:155431049-155895765 (-)
CBA/J ENSMUSG00210000355
 protein coding gene Chr3:155014391-155487299 (-)
CBA/J ENSMUSG00210000397
 lncRNA gene Chr3:154998693-155007622 (-)
DBA/2J ENSMUSG00185000055
 protein coding gene Chr3:155665066-156137981 (-)
DBA/2J ENSMUSG00185000141
 lncRNA gene Chr3:155649368-155658297 (-)
FVB/NJ ENSMUSG00205000099
 protein coding gene Chr3:153927411-154406619 (-)
FVB/NJ ENSMUSG00205000114
 lncRNA gene Chr3:153911719-153920644 (-)
JF1/MsJ ENSUMUG00000000086
 lncRNA gene Chr3:154390257-154399203 (-)
JF1/MsJ ENSUMUG00000000046
 protein coding gene Chr3:154405994-154865522 (-)
LP/J ENSMUSG00230008920
 protein coding gene Chr3:157534120-158007290 (-)
LP/J ENSMUSG00230009711
 lncRNA gene Chr3:157518420-157527351 (-)
NOD/ShiLtJ ENSMUSG00190007434
 protein coding gene Chr3:156017441-156492917 (-)
NOD/ShiLtJ ENSMUSG00190007581
 lncRNA gene Chr3:156001747-156010672 (-)
NZO/HlLtJ ENSMUSG00225005917
 protein coding gene Chr3:160059439-160532362 (-)
NZO/HlLtJ ENSMUSG00225006195
 lncRNA gene Chr3:160043743-160052672 (-)
PWK/PhJ ENSLUMG00010000044
 protein coding gene Chr3:154349374-154822506 (-)
PWK/PhJ ENSLUMG00010000053
 lncRNA gene Chr3:154333672-154342603 (-)
SPRET/EiJ ENSMSPG00010000320
 lncRNA gene Chr3:155697502-155706434 (-)
SPRET/EiJ ENSMSPG00010000294
 protein coding gene Chr3:155713190-156192919 (-)
WSB/EiJ ENSIUOG00005003432
 lncRNA gene Chr3:155120724-155129715 (-)
WSB/EiJ ENSIUOG00005003402
 protein coding gene Chr3:155136473-155605120 (-)



Homology
more
  • Human Ortholog
    LRRC7, leucine rich repeat containing 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC7, leucine rich repeat containing 7
  • Synonyms
    DENSIN, MRD77
  • Links
    NCBI Gene ID: 57554
    UniProt: Q96NW7

  • Chr Location
    1p31.1; chr1:69567922-70151945 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LRRC7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    39
  • Tissues
    5
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242274 NCBI Gene Model | MGI Sequence Detail 495432 C57BL/6J ±  kb
    transcript NM_001370781 RefSeq | MGI Sequence Detail 22635 C57BL/6  
    polypeptide Q80TE7 UniProt | EBI | MGI Sequence Detail 1490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442224
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory