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Nr1d1 Gene Detail
Summary
  • Symbol
    Nr1d1
  • Name
    nuclear receptor subfamily 1, group D, member 1
  • Synonyms
    A530070C09Rik, rev-erbA(alpha), REV-ERBalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444210
    NCBI Gene: 217166
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98658758-98666159 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444210
 protein coding gene Chr11:98658758-98666233 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019072
 protein coding gene Chr11:101369436-101376845 (-)
A/J MGP_AJ_G0019040
 protein coding gene Chr11:97124527-97131928 (-)
AKR/J MGP_AKRJ_G0019010
 protein coding gene Chr11:100133276-100140676 (-)
BALB/cJ MGP_BALBcJ_G0019014
 protein coding gene Chr11:97620502-97627903 (-)
C3H/HeJ MGP_C3HHeJ_G0018827
 protein coding gene Chr11:100276379-100283788 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019465
 protein coding gene Chr11:104472766-104480167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017097
 protein coding gene Chr11:94683470-94690862 (-)
CAST/EiJ MGP_CASTEiJ_G0018381
 protein coding gene Chr11:101264914-101272312 (-)
CBA/J MGP_CBAJ_G0018798
 protein coding gene Chr11:108820328-108827729 (-)
DBA/2J MGP_DBA2J_G0018906
 protein coding gene Chr11:96683155-96690564 (-)
FVB/NJ MGP_FVBNJ_G0018895
 protein coding gene Chr11:96198430-96205839 (-)
LP/J MGP_LPJ_G0018976
 protein coding gene Chr11:101824834-101832243 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018922
 protein coding gene Chr11:108538060-108545461 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019505
 protein coding gene Chr11:100484247-100491648 (-)
PWK/PhJ MGP_PWKPhJ_G0018152
 protein coding gene Chr11:97724331-97751771 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017941
 protein coding gene Chr11:100222023-100253111 (-)
WSB/EiJ MGP_WSBEiJ_G0018430
 protein coding gene Chr11:100435167-100442567 (-)



Homology
more
  • Human Ortholog
    NR1D1, nuclear receptor subfamily 1 group D member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1D1, nuclear receptor subfamily 1 group D member 1
  • Synonyms
    ear-1, EAR1, hRev, REVERBA, REVERBalpha, THRA1, THRAL
  • Links
    NCBI Gene ID: 9572
    neXtProt AC: NX_P20393
    UniProt: P20393

  • Chr Location
    17q21.1; chr17:40092793-40100589 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NR1D1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 6 alleles in 8 genetic backgrounds
    7 phenotypes from multigenic genotypes
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered circadian behavior and temperature regulation with mild alterations in cytoarchitecture of the cerebellum. Litter size is reduced by half in mutant females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    160
  • cDNA Data
    16
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020889 Ensembl Gene Model | MGI Sequence Detail 7402 C57BL/6J ±  kb
    transcript ENSMUST00000064941 Ensembl | MGI Sequence Detail 2721 Not Applicable  
    polypeptide ENSMUSP00000069505 Ensembl | MGI Sequence Detail 615 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000011392 nuclear receptor subfamily 1 group D member 1
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2144703
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 18
      Gene Ontology 30
      Phenotypes 105
    • Earliest
      J:23754 Forman BM, et al., Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol. 1994 Sep;8(9):1253-61
    • Latest
      J:345996 Makhija S, et al., REV-ERB activation as a novel pharmacological approach for treating inflammatory pain. Front Pharmacol. 2023;14:1171931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory