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Tnfrsf21 Gene Detail
Summary
  • Symbol
    Tnfrsf21
  • Name
    tumor necrosis factor receptor superfamily, member 21
  • Synonyms
    Death receptor 6, DR6, TR7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151075
    NCBI Gene: 94185
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43327446-43400079 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.69 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    867 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151075
 protein coding gene Chr17:43327446-43400080 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023771
 protein coding gene Chr17:43888584-43962324 (+)
A/J MGP_AJ_G0023729
 protein coding gene Chr17:42899644-42972710 (+)
AKR/J MGP_AKRJ_G0023700
 protein coding gene Chr17:43114688-43190051 (+)
BALB/cJ MGP_BALBcJ_G0023733
 protein coding gene Chr17:42791880-42864774 (+)
C3H/HeJ MGP_C3HHeJ_G0023497
 protein coding gene Chr17:43814791-43890722 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024176
 protein coding gene Chr17:45835952-45913660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021626
 protein coding gene Chr17:39762282-39834784 (+)
CAST/EiJ MGP_CASTEiJ_G0022978
 protein coding gene Chr17:43821648-43897481 (+)
CBA/J MGP_CBAJ_G0023473
 protein coding gene Chr17:47471340-47550912 (+)
DBA/2J MGP_DBA2J_G0023599
 protein coding gene Chr17:41712893-41784257 (+)
FVB/NJ MGP_FVBNJ_G0023566
 protein coding gene Chr17:41268405-41343002 (+)
LP/J MGP_LPJ_G0023680
 protein coding gene Chr17:44529065-44605719 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023595
 protein coding gene Chr17:47118193-47197261 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024221
 protein coding gene Chr17:43460839-43537023 (+)
PWK/PhJ MGP_PWKPhJ_G0022723
 protein coding gene Chr17:40955069-41029210 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022538
 protein coding gene Chr17:40339913-40414316 (+)
WSB/EiJ MGP_WSBEiJ_G0023043
 protein coding gene Chr17:43986261-44063208 (+)



Homology
more
  • Human Ortholog
    TNFRSF21, TNF receptor superfamily member 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF21, TNF receptor superfamily member 21
  • Synonyms
    BM-018, CD358, DR6
  • Links
    NCBI Gene ID: 27242
    neXtProt AC: NX_O75509
    UniProt: O75509

  • Chr Location
    6p12.3; chr6:47231532-47309905 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 5 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    983
  • Tissues
    55
  • cDNA Data
    80
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94185 NCBI Gene Model | MGI Sequence Detail 72634 C57BL/6J ±  kb
    transcript NM_178589 RefSeq | MGI Sequence Detail 3626 C57BL/6  
    polypeptide Q9EPU5 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146783, MGI:2147154
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory