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Kiss1r Gene Detail
Summary
  • Symbol
    Kiss1r
  • Name
    KISS1 receptor
  • Synonyms
    Gpr54
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148793
    NCBI Gene: 114229
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79752805-79758107 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148793
 protein coding gene Chr10:79752786-79759922 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017471
 protein coding gene Chr10:80482159-80487461 (+)
A/J MGP_AJ_G0017449
 protein coding gene Chr10:77672055-77677357 (+)
AKR/J MGP_AKRJ_G0017410
 protein coding gene Chr10:79790539-79795842 (+)
BALB/cJ MGP_BALBcJ_G0017411
 protein coding gene Chr10:77900661-77904429 (+)
C3H/HeJ MGP_C3HHeJ_G0017234
 protein coding gene Chr10:79894328-79899628 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017865
 protein coding gene Chr10:83261576-83266601 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015553
 protein coding gene Chr10:73900127-73905661 (+)
CAST/EiJ MGP_CASTEiJ_G0016801
 protein coding gene Chr10:80084145-80089278 (+)
CBA/J MGP_CBAJ_G0017206
 protein coding gene Chr10:86485809-86489711 (+)
DBA/2J MGP_DBA2J_G0017312
 protein coding gene Chr10:76887390-76892998 (+)
FVB/NJ MGP_FVBNJ_G0017306
 protein coding gene Chr10:76065724-76071027 (+)
LP/J MGP_LPJ_G0017383
 protein coding gene Chr10:80959294-80964595 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017332
 protein coding gene Chr10:88457341-88462763 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017906
 protein coding gene Chr10:79775956-79783404 (+)
PWK/PhJ MGP_PWKPhJ_G0016582
 protein coding gene Chr10:76753244-76758617 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016371
 protein coding gene Chr10:78748647-78753941 (+)
WSB/EiJ MGP_WSBEiJ_G0016861
 protein coding gene Chr10:79798809-79804087 (+)



Homology
more
  • Human Ortholog
    KISS1R, KISS1 receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KISS1R, KISS1 receptor
  • Synonyms
    AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
  • Links
    NCBI Gene ID: 84634
    neXtProt AC: NX_Q969F8
    UniProt: Q969F8

  • Chr Location
    19p13.3; chr19:917287-921005 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kiss1r mouse models; 3 with human KISS1R associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    115 phenotypes from 10 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations result in male and female infertility associated with abnormal sexual maturation and hypogonadotropic hypogonadism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    25
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035773 Ensembl Gene Model | MGI Sequence Detail 5303 C57BL/6J ±  kb
    transcript ENSMUST00000045529 Ensembl | MGI Sequence Detail 3163 Not Applicable  
    polypeptide ENSMUSP00000040516 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 7
      Phenotypes 68
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory