Akr1c14 MGI Mouse Gene Detail - MGI:2145458 - aldo-keto reductase family 1, member C14

Symbol

Akr1c14
Name

aldo-keto reductase family 1, member C14
Synonyms

9030611N15Rik

Feature Type

protein coding gene
IDs

MGI:2145458
NCBI Gene: 105387
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:4099015-4140569 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 2.26 cM
Mapping Data

4 experiments

SNPs within 2kb

768 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145458	protein coding gene	Chr13:4099011-4140688 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020202	protein coding gene	Chr13:537285-568076 (+)
A/J	MGP_AJ_G0020158	protein coding gene	Chr13:630250-661194 (+)
AKR/J	MGP_AKRJ_G0020133	protein coding gene	Chr13:656258-687611 (+)
BALB/cJ	MGP_BALBcJ_G0020141	protein coding gene	Chr13:634289-665158 (+)
C3H/HeJ	MGP_C3HHeJ_G0019945	protein coding gene	Chr13:719092-749939 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020588	protein coding gene	Chr13:611556-643280 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018200	protein coding gene	Chr13:539561-573150 (+)
CAST/EiJ	MGP_CASTEiJ_G0019485	protein coding gene	Chr13:551751-584428 (+)
CBA/J	MGP_CBAJ_G0019912	protein coding gene	Chr13:623302-655308 (+)
DBA/2J	MGP_DBA2J_G0020029	protein coding gene	Chr13:552223-586689 (+)
FVB/NJ	MGP_FVBNJ_G0020014	protein coding gene	Chr13:524560-556220 (+)
LP/J	MGP_LPJ_G0020103	protein coding gene	Chr13:601914-634722 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020050	protein coding gene	Chr13:666310-702118 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020616	protein coding gene	Chr13:611067-643295 (+)
PWK/PhJ	MGP_PWKPhJ_G0019247	protein coding gene	Chr13:611983-643452 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019052	protein coding gene	Chr13:655716-675954 (+)
WSB/EiJ	MGP_WSBEiJ_G0019543	protein coding gene	Chr13:548303-590521 (+)

Human Ortholog

AKR1C1, aldo-keto reductase family 1 member C1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKR1C1, aldo-keto reductase family 1 member C1
Synonyms

20-ALPHA-HSD, 2-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Links

HGNC:384

NCBI Gene ID: 1645

UniProt: Q04828
Chr Location

10p15.1; chr10:4963253-4983283 (+) GRCh38

Human Ortholog

AKR1C2, aldo-keto reductase family 1 member C2
Synonyms

AKR1C-pseudo, BABP, DD, DD-2, DD2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Links

HGNC:385

NCBI Gene ID: 1646

UniProt: P52895
Chr Location

10p15.1; chr10:4987775-5018031 (-) GRCh38

Human Ortholog

AKR1C3, aldo-keto reductase family 1 member C3
Synonyms

DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
Links

HGNC:386

NCBI Gene ID: 8644

UniProt: P42330
Chr Location

10p15.1; chr10:5035354-5107686 (+) GRCh38

Human Ortholog

AKR1C4, aldo-keto reductase family 1 member C4
Synonyms

3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
Links

HGNC:387

NCBI Gene ID: 1109

UniProt: P17516
Chr Location

10p15.1; chr10:5195462-5220608 (+) GRCh38

MGI Vertebrate Homology

Akr1c14 stringent orthology
4 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AKR1C1, AKR1C2, AKR1C3, AKR1C4
Protein SuperFamily

AKR
Gene Tree

Akr1c14

Diseases

5 with human AKR1C2,AKR1C3,AKR1C4 associations

				Human Disease	Mouse Models
				46,XY sex reversal 8 IDs 46,XY sex reversal 8 DOID:0111773 OMIM:614279 ORDO:443087
				alcohol dependence IDs alcohol dependence DOID:0050741 KEGG:05034 OMIM:103780
				B-lymphoblastic leukemia/lymphoma IDs B-lymphoblastic leukemia/lymphoma DOID:0080630 NCI:C8936 UMLS_CUI:C0862030
				leukemia IDs leukemia DOID:1240 DOID:9145 ICD10CM:C95.90 ICD9CM:208 ICD9CM:208.9 MESH:D007938 NCI:C3161 UMLS_CUI:C0023418
				T-cell acute lymphoblastic leukemia IDs T-cell acute lymphoblastic leukemia DOID:5603 MESH:D015458 UMLS_CUI:C0023492

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a conditional allele activated in the placenta exhibit sex-linked myelination alteration and autism-like behaviors in male mice.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

667
Tissues

23
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS26218.1

Ensembl

ENSMUSG00000033715 (Evidence)
NCBI Gene

105387

			Length	Strain/Species	Flank
genomic	105387	NCBI Gene Model \| MGI Sequence Detail	41555	C57BL/6J	± kb
transcript	NM_134072	RefSeq \| MGI Sequence Detail	2445	C57BL/6
polypeptide	NP_598833	RefSeq \| MGI Sequence Detail	323	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR020471 Aldo-keto reductase

IPR018170 Aldo/keto reductase, conserved site

IPR044482 Aldo-keto reductase family 1 member C

IPR023210 NADP-dependent oxidoreductase domain

IPR036812 NADP-dependent oxidoreductase domain superfamily

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All nucleic 12

cDNA 9

Primer pair 3

Microarray probesets 4

Summaries

All 29

Developmental Gene Expression 5

Phenotypes 7
Earliest

J:354375 Hardy DO, et al., Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. Endocrinology. 2000 May;141(5):1608-17
Latest

J:370213 Windley SP, et al., NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis. Endocrinology. 2025 Jul 8;166(9)

TSS for Akr1c14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118211	Chr13:4098972-4098983 (+)	-37 bp
Tssr118212	Chr13:4099001-4099030 (+)	1 bp
Tssr118213	Chr13:4099040-4099043 (+)	27 bp
Tssr118214	Chr13:4109565-4109586 (+)	10,561 bp
Tssr118215	Chr13:4109587-4109600 (+)	10,579 bp
Tssr118216	Chr13:4109671-4109672 (+)	10,657 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/08/2026 MGI 6.24