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Clp1 Gene Detail
Summary
  • Symbol
    Clp1
  • Name
    CLP1, cleavage and polyadenylation factor I subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138968
    NCBI Gene: 98985
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84553466-84557631 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138968
 protein coding gene Chr2:84552448-84557694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025907
 protein coding gene Chr2:85409882-85415980 (-)
A/J MGP_AJ_G0025881
 protein coding gene Chr2:82107822-82112813 (-)
AKR/J MGP_AKRJ_G0025851
 protein coding gene Chr2:84221249-84227643 (-)
BALB/cJ MGP_BALBcJ_G0025878
 protein coding gene Chr2:82240815-82245803 (-)
C3H/HeJ MGP_C3HHeJ_G0025637
 protein coding gene Chr2:84467278-84473609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026324
 protein coding gene Chr2:88055792-88060874 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023726
 protein coding gene Chr2:78933381-78938533 (-)
CAST/EiJ MGP_CASTEiJ_G0025098
 protein coding gene Chr2:84995899-85002224 (-)
CBA/J MGP_CBAJ_G0025618
 protein coding gene Chr2:91205727-91210717 (-)
DBA/2J MGP_DBA2J_G0025749
 protein coding gene Chr2:81646564-81651560 (-)
FVB/NJ MGP_FVBNJ_G0025712
 protein coding gene Chr2:80898856-80904440 (-)
LP/J MGP_LPJ_G0025837
 protein coding gene Chr2:85208378-85213367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025742
 protein coding gene Chr2:93530648-93536780 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026380
 protein coding gene Chr2:84448738-84467529 (-)
PWK/PhJ MGP_PWKPhJ_G0024842
 protein coding gene Chr2:81486790-81491846 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024646
 protein coding gene Chr2:84598803-84605028 (-)
WSB/EiJ MGP_WSBEiJ_G0025168
 protein coding gene Chr2:85128671-85134997 (-)



Homology
more
  • Human Ortholog
    CLP1, cleavage factor polyribonucleotide kinase subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLP1, cleavage factor polyribonucleotide kinase subunit 1
  • Synonyms
    hClp1, HEAB
  • Links
    NCBI Gene ID: 10978
    neXtProt AC: NX_Q92989
    UniProt: Q92989

  • Chr Location
    11q12.1; chr11:57648188-57661865 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clp1 mouse models; 1 with human CLP1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a kinase dead allele exhibit background sensitive lethality, motor neuron degeneration, defects in diaphragm innervation, progressive muscle weakness and impaired pre-tRNA processing. Mice homozygous for a globally targeted allele exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    46
  • cDNA Data
    67
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98985 NCBI Gene Model | MGI Sequence Detail 4166 C57BL/6J ±  kb
    transcript NM_133840 RefSeq | MGI Sequence Detail 1849 C57BL/6  
    polypeptide Q99LI9 UniProt | EBI | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005598 pre-mRNA cleavage complex II protein Clp1
      (term hierarchy)
    • EC
      2.7.1.78
    • InterPro Domains
      IPR038238 Clp1, C-terminal domain superfamily
      IPR032324 Clp1, N-terminal beta-sandwich domain
      IPR038239 Clp1, N-terminal beta-sandwich domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR028606 Polyribonucleotide 5-hydroxyl-kinase Clp1
      IPR045116 Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3
      IPR032319 Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain
      IPR010655 Pre-mRNA cleavage complex subunit Clp1, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:325410 LaForce GR, et al., Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration. Neuron. 2022 Apr 20;110(8):1340-1357.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory