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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Clp1
CLP1, cleavage and polyadenylation factor I subunit
MGI:2138968
54 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Clp1em1Slac/Clp1em1Slac
C57BL/6J-Clp1em1Slac/J 		abnormal cerebellum dentate nucleus morphology J:311491
abnormal gait J:311491
decreased body weight J:311491
decreased grip strength J:311491
decreased locomotor activity J:311491
impaired coordination J:311491
tremors J:311491
Clp1em1Slac/Clp1em2Slac
C57BL/6J-Clp1em1Slac/Clp1em2Slac 		abnormal autopod morphology J:311491
abnormal cerebellar hemisphere morphology J:311491
abnormal cerebellum dentate nucleus morphology J:311491
abnormal cerebellum vermis morphology J:311491
abnormal gait J:311491
abnormal limb posture J:311491
cerebellum atrophy J:311491
decreased body weight J:311491
decreased grip strength J:311491
decreased locomotor activity J:311491
decreased spinal cord size J:311491
impaired coordination J:311491
kyphosis J:311491
motor neuron degeneration J:311491
postnatal lethality, incomplete penetrance J:311491
tremors J:311491
Clp1em2Slac/Clp1em2Slac
C57BL/6J-Clp1em2Slac/J 		embryonic lethality prior to organogenesis, complete penetrance J:311491
Clp1tm1.1Pngr/Clp1tm1.1Pngr
B6.Cg-Clp1tm1.1Pngr 		abnormal neuromuscular synapse morphology J:196364
abnormal olfactory bulb morphology J:209564
abnormal phrenic nerve innervation pattern to diaphragm J:196364
decreased birth weight J:196364
decreased brain size J:209564
decreased brain weight J:209564
decreased motor neuron number J:196364
decreased neuron number J:209564
defasiculated phrenic nerve J:196364
hyporesponsive to tactile stimuli J:196364
increased neuron apoptosis J:209564
lordosis J:196364
microcephaly J:209564
motor neuron degeneration J:196364
neonatal lethality, complete penetrance J:196364
respiratory failure J:196364
normal respiratory system phenotype J:196364
thin cerebral cortex J:209564
Clp1tm1.1Pngr/Clp1tm1.1Pngr
C.Cg-Clp1tm1.1Pngr 		lethality, complete penetrance J:196364
Clp1tm1.1Pngr/Clp1tm1.1Pngr
CBA.Cg-Clp1tm1.1Pngr 		abnormal axon morphology J:196364
abnormal gait J:196364
abnormal microglial cell morphology J:209564
abnormal motor coordination/balance J:196364
abnormal neuromuscular synapse morphology J:196364
abnormal sciatic nerve morphology J:196364
ataxia J:196364
axon degeneration J:196364
normal behavior/neurological phenotype J:196364
decreased brain size J:209564
decreased brain weight J:209564
decreased motor neuron number J:196364
decreased neuron number J:209564
impaired balance J:196364
maternal effect J:196364
microcephaly J:209564
normal mortality/aging J:196364
normal nervous system phenotype J:196364, J:209564
paralysis J:196364
premature death J:196364
progressive muscle weakness J:196364
skeletal muscle atrophy J:196364
thin cerebral cortex J:209564
Clp1tm1.1Pngr/Clp1tm1.1Pngr
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell physiology J:196364
increased cellular sensitivity to oxidative stress J:196364
oxidative stress J:196364
Clp1tm1.1Pngr/Clp1tm1.1Pngr
Tg(Hlxb9-GFP)1Tmj/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA 		decreased motor neuron number J:196364
Clp1tm1.1Pngr/Clp1tm1.1Pngr
Tg(Mnx1-Clp1,-EGFP)#Pngr/0
involves: 129P2/OlaHsd * C57BL/6J 		normal mortality/aging J:196364
normal nervous system phenotype J:196364
Clp1tm2.2Pngr/Clp1tm2.2Pngr
involves: 129P2/OlaHsd * C57BL/6J 		embryonic lethality, complete penetrance J:196364
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory