Phenotypes Associated with This Genotype

Genotype
MGI:6771475

• Allelic Composition: Clp1^em1Slac/Clp1^em1Slac
• Genetic Background: C57BL/6J-Clp1^em1Slac/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:311491 )

• females, but not males, weight less than wild-type mice at 1 month of age

• both females and males weigh 21-30% less than wild-type mice at 5 and 9 months of age

behavior/neurological

tremors ( J:311491 )

• mice develop a mild tremor by 4 months of age

impaired coordination ( J:311491 )

• 5-month-old mice, but not 1-month-old mice, perform poorly on the accelerating rotarod test, with rotarod durations of 51% of wild-type values

decreased grip strength ( J:311491 )

• 5-month-old mice, but not 1-month-old mice, perform poorly on the rolling wire-hang test, with wire hang durations of 39% of wild-type values

abnormal gait ( J:311491 )

• mice develop a halting gait by 4 months of age

decreased locomotor activity ( J:311491 )

• 5-month-old mice, but not 1-month-old mice, perform poorly on the treadmill task, with treadmill walking percentages of 28% of wild-type values

nervous system

abnormal cerebellum dentate nucleus morphology ( J:311491 )

• large neurons in the dentate nuclei are less abundant in 9-month-old mice

• however, aged mice exhibit normal cerebellar measurements

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pontocerebellar hypoplasia type 10		DOID:0060279	OMIM:615803	J:311491