About   Help   FAQ
Irx6 Gene Detail
Summary
  • Symbol
    Irx6
  • Name
    Iroquois homeobox 6
Location &
Maps
more
  • Sequence Map
    Chr8:93400917-93407584 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927642
 protein coding gene Chr8:93400916-93407584 (+)
129S1/SvImJ ENSMUSG00200017082
 protein coding gene Chr8:87762982-87769648 (+)
A/J ENSMUSG00195025576
 protein coding gene Chr8:88130564-88137232 (+)
AKR/J ENSMUSG00220034385
 protein coding gene Chr8:88134094-88140760 (+)
BALB/cJ ENSMUSG00180017907
 protein coding gene Chr8:87959733-87966396 (+)
C3H/HeJ ENSMUSG00175024210
 protein coding gene Chr8:88068811-88075479 (+)
C57BL/6NJ ENSMUSG00215024319
 protein coding gene Chr8:87671086-87677755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031372
 protein coding gene Chr8:84195666-84202250 (+)
CAST/EiJ ENSTCUG00005016267
 protein coding gene Chr8:87535816-87542472 (+)
CBA/J ENSMUSG00210035176
 protein coding gene Chr8:88009622-88016285 (+)
DBA/2J ENSMUSG00185023173
 protein coding gene Chr8:94118356-94125021 (+)
FVB/NJ ENSMUSG00205015312
 protein coding gene Chr8:87089284-87095945 (+)
JF1/MsJ ENSUMUG00000018355
 protein coding gene Chr8:96471901-96478563 (+)
LP/J ENSMUSG00230027560
 protein coding gene Chr8:97756828-97763494 (+)
NOD/ShiLtJ ENSMUSG00190013765
 protein coding gene Chr8:88116407-88123067 (+)
NZO/HlLtJ ENSMUSG00225038734
 protein coding gene Chr8:101158856-101165517 (+)
PWK/PhJ ENSLUMG00010033389
 protein coding gene Chr8:87798525-87805178 (+)
SPRET/EiJ ENSMSPG00010028741
 protein coding gene Chr8:89771077-89776834 (+)
WSB/EiJ ENSIUOG00005018947
 protein coding gene Chr8:88846016-88852672 (+)



Homology
more
  • Human Ortholog
    IRX6, iroquois homeobox 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX6, iroquois homeobox 6
  • Synonyms
    IRX-3, IRX7, IRXB3
  • Links
    NCBI Gene ID: 79190
    UniProt: P78412

  • Chr Location
    16q12.2; chr16:55323974-55330757 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    144
  • cDNA Data
    11
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64379 NCBI Gene Model | MGI Sequence Detail 6668 C57BL/6J ±  kb
    transcript NM_022428 RefSeq | MGI Sequence Detail 3369 ZRU/MplStud  
    polypeptide Q9ER75 UniProt | EBI | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 12
      Primer pair 2
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 23
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:61328 Cohen DR, et al., Expression of two novel mouse iroquois homeobox genes during neurogenesis. Mech Dev. 2000 Mar 1;91(1-2):317-21
    • Latest
      J:365021 Catela C, et al., The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets involved in motor neuron development. iScience. 2025 Apr 18;28(4):112210
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory