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Adgrg6 Gene Detail
Summary
  • Symbol
    Adgrg6
  • Name
    adhesion G protein-coupled receptor G6
  • Synonyms
    1190004A11Rik, DREG, Gpr126, LOC215798
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916151
    NCBI Gene: 215798
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:14278327-14421403 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 5.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4288 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916151
 protein coding gene Chr10:14278327-14421467 (-)
129S1/SvImJ ENSMUSG00200009484
 protein coding gene Chr10:11301018-11444172 (-)
A/J ENSMUSG00195006770
 protein coding gene Chr10:11212511-11355769 (-)
AKR/J ENSMUSG00220009930
 protein coding gene Chr10:11324900-11468051 (-)
BALB/cJ ENSMUSG00180014925
 protein coding gene Chr10:11369427-11512696 (-)
C3H/HeJ ENSMUSG00175019485
 protein coding gene Chr10:11365615-11508869 (-)
C57BL/6NJ ENSMUSG00215003342
 protein coding gene Chr10:11232037-11375130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015130
 protein coding gene Chr10:10658380-10796632 (-)
CAST/EiJ ENSTCUG00005028781
 protein coding gene Chr10:11227057-11364644 (-)
CBA/J ENSMUSG00210015369
 protein coding gene Chr10:11315328-11458554 (-)
DBA/2J ENSMUSG00185007113
 protein coding gene Chr10:11375625-11513195 (-)
FVB/NJ ENSMUSG00205013565
 protein coding gene Chr10:11416102-11554320 (-)
JF1/MsJ ENSUMUG00000011098
 protein coding gene Chr10:11418075-11555617 (-)
LP/J ENSMUSG00230016244
 protein coding gene Chr10:12968635-13111882 (-)
NOD/ShiLtJ ENSMUSG00190010730
 protein coding gene Chr10:11347404-11490547 (-)
NZO/HlLtJ ENSMUSG00225015344
 protein coding gene Chr10:17487335-17630511 (-)
PWK/PhJ ENSLUMG00010015138
 protein coding gene Chr10:11134110-11278018 (-)
SPRET/EiJ ENSMSPG00010010461
 protein coding gene Chr10:11585230-11722544 (-)
WSB/EiJ ENSIUOG00005021160
 protein coding gene Chr10:10951031-11094174 (-)



Homology
more
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRG6, adhesion G protein-coupled receptor G6
  • Synonyms
    APG1, DREG, GPR126, LCCS9, PR126, PS1TP2, VIGR
  • Links
    NCBI Gene ID: 57211
    UniProt: Q86SQ4

  • Chr Location
    6q24.2; chr6:142301854-142446266 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adgrg6 mouse models; 1 with human ADGRG6 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 7 alleles in 11 genetic backgrounds
    3 phenotypes from multigenic genotypes
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die during organogenesis and display signs of circulatory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    113
  • cDNA Data
    33
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039116 Ensembl Gene Model | MGI Sequence Detail 143077 C57BL/6J ±  kb
    transcript ENSMUST00000238680 Ensembl | MGI Sequence Detail 4482 Not Applicable  
    polypeptide ENSMUSP00000158717 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029514 adhesion G-protein coupled receptor G6
      (term hierarchy)
    • InterPro Domains
      IPR057333 Adhesion GPCR Gpr126, SEA domain
      IPR058857 Adhesion G-protein coupled receptor G2/6, GAIN domain
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000859 CUB domain
      IPR046338 GAIN domain superfamily
      IPR057244 GAIN, subdomain B
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR001759 Pentraxin domain
      IPR035914 Spermadhesin, CUB domain superfamily
    • GlyGen
      Q6F3F9 25 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 33
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143604, MGI:2143793, MGI:2685068
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 18
      Phenotypes 26
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:375698 Yang Z, et al., A force-sensitive adhesion GPCR is required for equilibrioception. Cell Res. 2025 Apr;35(4):243-264
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory