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Tubb4b Gene Detail
Summary
  • Symbol
    Tubb4b
  • Name
    tubulin, beta 4B class IVB
  • Synonyms
    4930542G03Rik, MGC:28623, MGC:6713, Tubb2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915472
    NCBI Gene: 227613
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25112172-25114714 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.08 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915472
 protein coding gene Chr2:25112170-25114714 (-)
129S1/SvImJ ENSMUSG00200049440
 protein coding gene Chr2:22096305-22098847 (-)
A/J ENSMUSG00195023479
 protein coding gene Chr13:88745470-88747018 (-)
A/J ENSMUSG00195048622
 protein coding gene Chr2:22187046-22189588 (-)
AKR/J ENSMUSG00220053271
 protein coding gene Chr2:22304876-22307418 (-)
BALB/cJ ENSMUSG00180051661
 protein coding gene Chr2:22197961-22200503 (-)
C3H/HeJ ENSMUSG00175048053
 protein coding gene Chr2:22162135-22164677 (-)
C57BL/6NJ ENSMUSG00215046883
 protein coding gene Chr2:22220832-22223374 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023254
 protein coding gene Chr2:21119542-21122076 (-)
CAST/EiJ ENSTCUG00005050967
 protein coding gene Chr2:21939392-21941930 (-)
CBA/J ENSMUSG00210015560
 protein coding gene Chr2:22201114-22203656 (-)
DBA/2J ENSMUSG00185052773
 protein coding gene Chr2:22101307-22103849 (-)
FVB/NJ ENSMUSG00205046191
 protein coding gene Chr2:21954930-21957472 (-)
JF1/MsJ ENSUMUG00000055531
 protein coding gene Chr2:22014621-22017164 (-)
LP/J ENSMUSG00230038234
 protein coding gene Chr2:24032306-24034848 (-)
NOD/ShiLtJ ENSMUSG00190033220
 protein coding gene Chr2:22192147-22194689 (-)
NZO/HlLtJ ENSMUSG00225010317
 protein coding gene Chr2:31782967-31785509 (-)
PWK/PhJ ENSLUMG00010042545
 protein coding gene Chr2:22112577-22115118 (-)
SPRET/EiJ ENSMSPG00010029975
 protein coding gene Chr2:22799596-22802134 (-)
WSB/EiJ ENSIUOG00005051891
 protein coding gene Chr2:22059452-22061994 (-)



Homology
more
  • Human Ortholog
    TUBB4B, tubulin beta 4B class IVb
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBB4B, tubulin beta 4B class IVb
  • Synonyms
    Beta2, LCAEOD, TUBB2, TUBB2C
  • Links
    NCBI Gene ID: 10383
    UniProt: P68371

  • Chr Location
    9q34.3; chr9:137241287-137243707 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tubb4b mouse models; 1 with human TUBB4B associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 9 alleles in 10 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial postnatal lethality and severe truncation of cilia on multi-ciliated cells. Homozygosity for a knockout allele, homozygosity for the p.R391H allele, or heterozygosity for the p.R391C allele leads to male infertility. Homozygous knockout leads to hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    24
  • cDNA Data
    13
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036752 Ensembl Gene Model | MGI Sequence Detail 2543 C57BL/6J ±  kb
    transcript ENSMUST00000043584 Ensembl | MGI Sequence Detail 1598 Not Applicable  
    polypeptide ENSMUSP00000042342 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1
      Antibodies 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 34
      Diseases 1
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
    • Latest
      J:360308 Dodd DO, et al., Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules. Science. 2024 Apr 26;384(6694):eadf5489
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory