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Sppl2a Gene Detail
Summary
  • Symbol
    Sppl2a
  • Name
    signal peptide peptidase like 2A
  • Synonyms
    2010106G01Rik, C130089K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913802
    NCBI Gene: 66552
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126732311-126775155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    294 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913802
protein coding gene Chr2:126732311-126775706 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026446
protein coding gene Chr2:130129928-130174139 (-)
A/J MGP_AJ_G0026410
protein coding gene Chr2:124862534-124906051 (-)
AKR/J MGP_AKRJ_G0026385
protein coding gene Chr2:128425829-128471443 (-)
BALB/cJ MGP_BALBcJ_G0026422
protein coding gene Chr2:125133874-125176400 (-)
C3H/HeJ MGP_C3HHeJ_G0026165
protein coding gene Chr2:128938067-128983174 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026867
protein coding gene Chr2:134260975-134303544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024244
protein coding gene Chr2:119581131-119623922 (-)
CAST/EiJ MGP_CASTEiJ_G0025626
protein coding gene Chr2:129149675-129195193 (-)
CBA/J MGP_CBAJ_G0026145
protein coding gene Chr2:139194107-139243902 (-)
DBA/2J MGP_DBA2J_G0026279
protein coding gene Chr2:124276493-124319685 (-)
FVB/NJ MGP_FVBNJ_G0026243
protein coding gene Chr2:122927886-122972352 (-)
LP/J MGP_LPJ_G0026384
protein coding gene Chr2:130380816-130424060 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026263
protein coding gene Chr2:143254821-143299746 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026922
protein coding gene Chr2:128464387-128508566 (-)
PWK/PhJ MGP_PWKPhJ_G0025362
protein coding gene Chr2:123818692-123862696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025164
protein coding gene Chr2:127537039-127580099 (-)
WSB/EiJ MGP_WSBEiJ_G0025700
protein coding gene Chr2:129347569-129394281 (-)



Homology
more
  • Human Ortholog
    SPPL2A, signal peptide peptidase like 2A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPPL2A, signal peptide peptidase like 2A
  • Synonyms
    IMD86, IMP3, PSL2
  • Links
    NCBI Gene ID: 84888
    neXtProt AC: NX_Q8TCT8
    UniProt: Q8TCT8

  • Chr Location
    15q21.2; chr15:50702266-50765948 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SPPL2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased immunoglobulin prior to and after immunization and decreased splenic B cells, myeloid dendritic cells, T2 B cells and follicular B cells. Mice homozygous for a hypomorphic allele exhibit similar albeit less severe phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027366 Ensembl Gene Model | MGI Sequence Detail 42845 C57BL/6J ±  kb
    transcript ENSMUST00000028844 Ensembl | MGI Sequence Detail 5616 Not Applicable  
    polypeptide ENSMUSP00000028844 Ensembl | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 121

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442382
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:329412 Ballin M, et al., The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins. FEBS J. 2022 Sep 1;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory