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Sppl2a Gene Detail
Summary
  • Symbol
    Sppl2a
  • Name
    signal peptide peptidase like 2A
  • Synonyms
    2010106G01Rik, C130089K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913802
    NCBI Gene: 66552
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126732311-126775155 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    972 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913802
 protein coding gene Chr2:126732311-126775706 (-)
129S1/SvImJ ENSMUSG00200043921
 protein coding gene Chr2:123792331-123835100 (-)
A/J ENSMUSG00195029793
 protein coding gene Chr2:123812808-123855677 (-)
AKR/J ENSMUSG00220037515
 protein coding gene Chr2:123578570-123621370 (-)
BALB/cJ ENSMUSG00180046041
 protein coding gene Chr2:123599737-123642601 (-)
C3H/HeJ ENSMUSG00175039314
 protein coding gene Chr2:124154817-124197204 (-)
C57BL/6NJ ENSMUSG00215020859
 protein coding gene Chr2:123653584-123696431 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024244
 protein coding gene Chr2:119581131-119623922 (-)
CAST/EiJ ENSTCUG00005034283
 protein coding gene Chr2:122948824-122991108 (-)
CBA/J ENSMUSG00210031874
 protein coding gene Chr2:124005369-124047764 (-)
DBA/2J ENSMUSG00185031191
 protein coding gene Chr2:123659463-123701857 (-)
FVB/NJ ENSMUSG00205029833
 protein coding gene Chr2:122815400-122858191 (-)
JF1/MsJ ENSUMUG00000014749
 protein coding gene Chr2:123509085-123551444 (-)
LP/J ENSMUSG00230035559
 protein coding gene Chr2:125427773-125470545 (-)
NOD/ShiLtJ ENSMUSG00190013983
 protein coding gene Chr2:123785568-123828345 (-)
NZO/HlLtJ ENSMUSG00225026589
 protein coding gene Chr2:133333942-133376722 (-)
PWK/PhJ ENSLUMG00010034848
 protein coding gene Chr2:123396095-123438371 (-)
SPRET/EiJ ENSMSPG00010029619
 protein coding gene Chr2:125826851-125868881 (-)
WSB/EiJ ENSIUOG00005038563
 protein coding gene Chr2:123588964-123633064 (-)



Homology
more
  • Human Ortholog
    SPPL2A, signal peptide peptidase like 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPPL2A, signal peptide peptidase like 2A
  • Synonyms
    IMD86, IMP3, PSL2
  • Links
    NCBI Gene ID: 84888
    UniProt: Q8TCT8

  • Chr Location
    15q21.2; chr15:50702266-50765948 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPPL2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased immunoglobulin prior to and after immunization and decreased splenic B cells, myeloid dendritic cells, T2 B cells and follicular B cells. Mice homozygous for a hypomorphic allele exhibit similar albeit less severe phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    18
  • cDNA Data
    120
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027366 Ensembl Gene Model | MGI Sequence Detail 42845 C57BL/6J ±  kb
    transcript ENSMUST00000028844 Ensembl | MGI Sequence Detail 5616 Not Applicable  
    polypeptide ENSMUSP00000028844 Ensembl | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 121

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442382
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:367703 Held S, et al., Physiological shedding and C-terminal proteolytic processing of TMEM106B. Cell Rep. 2025 Jan 28;44(1):115107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory