About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sppl2a
signal peptide peptidase like 2A
MGI:1913802
33 phenotypes from 6 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Sppl2achompB/Sppl2achompB
involves: C57BL/6 		abnormal class switch recombination J:194595
abnormal humoral immune response J:194595
decreased activation-induced B cell apoptosis J:194595
decreased B cell proliferation J:194595
decreased follicular B cell number J:194595
decreased IgG1 level J:194595
decreased IgG2b level J:194595
decreased IgG3 level J:194595
decreased IgM level J:194595
decreased marginal zone B cell number J:194595
decreased mature B cell number J:194595
decreased myeloid dendritic cell number J:194595
decreased plasmacytoid dendritic cell number J:194595
decreased transitional stage T2 B cell number J:194595
normal immune system phenotype J:194595
Sppl2am1Anu/Sppl2am1Anu
involves: C57BL/6JAnu 		abnormal immunoglobulin level J:194663
abnormal mature B cell morphology J:194663
abnormal transitional stage B cell morphology J:194663
decreased IgG1 level J:194663
decreased IgM level J:194663
decreased marginal zone B cell number J:194663
decreased transitional stage T2 B cell number J:194663
decreased transitional stage T3 B cell number J:194663
normal hematopoietic system phenotype J:194663
Sppl2am1Btlr/Sppl2am1Btlr
C57BL/6J-Sppl2am1Btlr 		decreased IgG level J:236687
decreased response to antigen J:236687
Sppl2am2Btlr/Sppl2am2Btlr
C57BL/6J-Sppl2am2Btlr 		decreased IgG level J:236688
decreased IgM level J:236688
decreased response to antigen J:236688
Sppl2atm1Basc/Sppl2atm1Basc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl 		abnormal B cell physiology J:194664
arrested B cell differentiation J:194664
decreased B cell number J:194664
decreased B-1 B cell number J:194664
decreased B-2 B cell number J:194664
decreased follicular B cell number J:194664
decreased IgA level J:194664
decreased IgG1 level J:194664
decreased IgG2a level J:194664
decreased IgG2b level J:194664
decreased IgG3 level J:194664
decreased IgM level J:194664
decreased marginal zone B cell number J:194664
decreased mature B cell number J:194664
decreased Peyer's patch number J:194664
decreased T cell number J:194664
decreased transitional stage T2 B cell number J:194664
small Peyer's patches J:194664
small spleen J:194664
Sppl2atm1Dgen/Sppl2atm1Dgen
B6.129P2-Sppl2atm1Dgen 		decreased B cell number J:194595
decreased B-1 B cell number J:194595
decreased follicular B cell number J:194595
decreased IgA level J:194595
decreased IgG1 level J:194595
decreased IgG2b level J:194595
decreased IgG3 level J:194595
decreased IgM level J:194595
decreased myeloid dendritic cell number J:194595
decreased transitional stage T2 B cell number J:194595
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory