Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in membrane protein proteolysis and regulation of immune response. Located in late endosome membrane and lysosomal membrane. Is expressed in genitourinary system; skeleton; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A).