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Igf2bp1 Gene Detail
Summary
  • Symbol
    Igf2bp1
  • Name
    insulin-like growth factor 2 mRNA binding protein 1
  • Synonyms
    Crdbp, CRD-BP, D030026A21Rik, D11Moh40e, D11Moh45, IMP-1, IMP1, Zbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890357
    NCBI Gene: 140486
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95847989-95896766 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1224 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890357
 protein coding gene Chr11:95847989-95896770 (-)
129S1/SvImJ ENSMUSG00200052336
 protein coding gene Chr11:93092326-93141099 (-)
A/J ENSMUSG00195046877
 protein coding gene Chr11:92814432-92863280 (-)
AKR/J ENSMUSG00220045174
 protein coding gene Chr11:93073473-93122320 (-)
BALB/cJ ENSMUSG00180043125
 protein coding gene Chr11:93075601-93124450 (-)
C3H/HeJ ENSMUSG00175038440
 protein coding gene Chr11:93073730-93122569 (-)
C57BL/6NJ ENSMUSG00215053958
 protein coding gene Chr11:92665340-92714225 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017016
 protein coding gene Chr11:91722325-91770898 (-)
CAST/EiJ ENSTCUG00005050308
 protein coding gene Chr11:92518418-92567331 (-)
CBA/J ENSMUSG00210052443
 protein coding gene Chr11:92777014-92825854 (-)
DBA/2J ENSMUSG00185046035
 protein coding gene Chr11:93122157-93171068 (-)
FVB/NJ ENSMUSG00205039056
 protein coding gene Chr11:92979380-93028161 (-)
JF1/MsJ ENSUMUG00000017589
 protein coding gene Chr11:93429477-93478329 (-)
LP/J ENSMUSG00230050437
 protein coding gene Chr11:94175456-94224227 (-)
NOD/ShiLtJ ENSMUSG00190048467
 protein coding gene Chr11:93169303-93218146 (-)
NZO/HlLtJ ENSMUSG00225051536
 protein coding gene Chr11:96230432-96279441 (-)
PWK/PhJ ENSLUMG00010051019
 protein coding gene Chr11:92975000-93023670 (-)
SPRET/EiJ ENSMSPG00010043370
 protein coding gene Chr11:93465171-93513941 (-)
WSB/EiJ ENSIUOG00005049822
 protein coding gene Chr11:92918504-92967502 (-)



Homology
more
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGF2BP1, insulin like growth factor 2 mRNA binding protein 1
  • Synonyms
    CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
  • Links
    NCBI Gene ID: 10642
    UniProt: Q9NZI8

  • Chr Location
    17q21.32; chr17:48996558-49056145 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this locus results in increased neonatal lethality, growth retardation, and impaired intestinal development. Males exhibit increased anxiety-like response and decreased exploratory behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    169
  • cDNA Data
    27
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013415 Ensembl Gene Model | MGI Sequence Detail 48778 C57BL/6J ±  kb
    transcript ENSMUST00000013559 Ensembl | MGI Sequence Detail 8378 Not Applicable  
    polypeptide ENSMUSP00000013559 Ensembl | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 13
      cDNA 28
      Primer pair 7
      Other 2
      Antibodies 8

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1330862, MGI:1343090, MGI:1343099, MGI:1343130, MGI:2138604, MGI:2144349, MGI:2442575
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 27
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:1689 Forejt J, et al., Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Cell. 1992 Aug 7;70(3):443-50
    • Latest
      J:384798 Rayee D, et al., RNA-binding proteins in the mouse lens: Functional classifications, expression profiling, and interaction studies of Carhsp1 with crystallin mRNAs. Dev Biol. 2026 Apr 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory