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Exosc10 Gene Detail
Summary
  • Symbol
    Exosc10
  • Name
    exosome component 10
  • Synonyms
    p2, p3, p4, PM-Scl, PM/Scl-100, Pmscl2, RRP6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355322
    NCBI Gene: 50912
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148642886-148666858 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355322
 protein coding gene Chr4:148642870-148666858 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029126
 protein coding gene Chr4:152295943-152319811 (+)
A/J MGP_AJ_G0029091
 protein coding gene Chr4:145992236-146016034 (+)
AKR/J MGP_AKRJ_G0029039
 protein coding gene Chr4:149965870-149990789 (+)
BALB/cJ MGP_BALBcJ_G0029107
 protein coding gene Chr4:146494872-146518729 (+)
C3H/HeJ MGP_C3HHeJ_G0028828
 protein coding gene Chr4:150528836-150553547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029556
 protein coding gene Chr4:157824100-157847950 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026802
 protein coding gene Chr4:138409486-138433491 (+)
CAST/EiJ MGP_CASTEiJ_G0028241
 protein coding gene Chr4:147737683-147761554 (+)
CBA/J MGP_CBAJ_G0028790
 protein coding gene Chr4:162397728-162440112 (+)
DBA/2J MGP_DBA2J_G0028939
 protein coding gene Chr4:146096932-146120905 (+)
FVB/NJ MGP_FVBNJ_G0028903
 protein coding gene Chr4:145189152-145214059 (+)
LP/J MGP_LPJ_G0029029
 protein coding gene Chr4:152248319-152275318 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028930
 protein coding gene Chr4:165717543-165742550 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029588
 protein coding gene Chr4:150453233-150483304 (+)
PWK/PhJ MGP_PWKPhJ_G0027961
 protein coding gene Chr4:142088051-142112382 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027795
 protein coding gene Chr4:144709570-144735817 (+)
WSB/EiJ MGP_WSBEiJ_G0028321
 protein coding gene Chr4:150621532-150645400 (+)



Homology
more
  • Human Ortholog
    EXOSC10, exosome component 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOSC10, exosome component 10
  • Synonyms
    p2, p3, p4, PM-Scl, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p
  • Links
    NCBI Gene ID: 5394
    neXtProt AC: NX_Q01780
    UniProt: Q01780

  • Chr Location
    1p36.22; chr1:11066618-11099869 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced female fertility with defective GVBD and endomembrane components.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    19
  • cDNA Data
    154
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017264 Ensembl Gene Model | MGI Sequence Detail 23973 C57BL/6J ±  kb
    transcript ENSMUST00000017408 Ensembl | MGI Sequence Detail 2790 Not Applicable  
    polypeptide ENSMUSP00000017408 Ensembl | MGI Sequence Detail 887 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 157
      Genomic 1
      cDNA 154
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:61080 Bliskovski V, et al., Structure and localization of mouse pmscl1 and pmscl2 genes. Genomics. 2000 Feb 15;64(1):106-10
    • Latest
      J:343201 Srinivasan S, et al., Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory