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Abcc2 Gene Detail
Summary
  • Symbol
    Abcc2
  • Name
    ATP-binding cassette, sub-family member 2
  • Synonyms
    Cmoat, Mrp2, multidrug resistance protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352447
    NCBI Gene: 12780
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43770747-43826771 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352447
 protein coding gene Chr19:43770631-43829179 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025158
 protein coding gene Chr19:43207809-43268587 (+)
A/J MGP_AJ_G0025135
 protein coding gene Chr19:41151298-41212419 (+)
AKR/J MGP_AKRJ_G0025103
 protein coding gene Chr19:42444102-42502525 (+)
BALB/cJ MGP_BALBcJ_G0025129
 protein coding gene Chr19:41193994-41258179 (+)
C3H/HeJ MGP_C3HHeJ_G0024889
 protein coding gene Chr19:42627558-42686129 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025572
 protein coding gene Chr19:44275721-44337063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022986
 protein coding gene Chr19:40448787-40505975 (+)
CAST/EiJ MGP_CASTEiJ_G0024354
 protein coding gene Chr19:42318983-42382498 (+)
CBA/J MGP_CBAJ_G0024869
 protein coding gene Chr19:46468256-46534760 (+)
DBA/2J MGP_DBA2J_G0025001
 protein coding gene Chr19:40973781-41038616 (+)
FVB/NJ MGP_FVBNJ_G0024962
 protein coding gene Chr19:40728065-40788976 (+)
LP/J MGP_LPJ_G0025087
 protein coding gene Chr19:43169346-43232669 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024993
 protein coding gene Chr19:46009428-46075350 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025630
 protein coding gene Chr19:42540851-42600959 (+)
PWK/PhJ MGP_PWKPhJ_G0024103
 protein coding gene Chr19:40872263-40932061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023907
 protein coding gene Chr19:41265303-41321726 (+)
WSB/EiJ MGP_WSBEiJ_G0024424
 protein coding gene Chr19:42678836-42740186 (+)



Homology
more
  • Human Ortholog
    ABCC2, ATP binding cassette subfamily C member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCC2, ATP binding cassette subfamily C member 2
  • Synonyms
    ABC30, CMOAT, cMRP, DJS, MRP2
  • Links
    NCBI Gene ID: 1244
    neXtProt AC: NX_Q92887
    UniProt: Q92887

  • Chr Location
    10q24.2; chr10:99782640-99852594 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human ABCC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urine bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    103
  • cDNA Data
    29
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12780 NCBI Gene Model | MGI Sequence Detail 56025 C57BL/6J ±  kb
    transcript NM_013806 RefSeq | MGI Sequence Detail 5389 C57L/J  
    polypeptide Q8VI47 UniProt | EBI | MGI Sequence Detail 1543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196442, MGI:2147483
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:42393 Lammert F, et al., The gene encoding the multispecific organic anion transporter of the hepatocyte canalicular membraine (Cmoat) maps to mouse Chromosome 19. Mamm Genome. 1998 Jan;9(1):87-88
    • Latest
      J:298936 Beer AJ, et al., Reduced Mrp2 surface availability as PI3Kgamma-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis. Sci Rep. 2020 Aug 4;10(1):13110
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory