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Macroh2a1 Gene Detail
Summary
  • Symbol
    Macroh2a1
  • Name
    macroH2A.1 histone
  • Synonyms
    H2AF12M, H2afy, MACROH2A1.2, mH2a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349392
    NCBI Gene: 26914
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56221435-56283439 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349392
 protein coding gene Chr13:56221432-56284174 (-)
129S1/SvImJ ENSMUSG00200016656
 protein coding gene Chr13:53095044-53157946 (-)
A/J ENSMUSG00195038575
 protein coding gene Chr13:52560513-52622623 (-)
AKR/J ENSMUSG00220042015
 protein coding gene Chr13:52101655-52163676 (-)
BALB/cJ ENSMUSG00180016066
 protein coding gene Chr13:52806221-52868333 (-)
C3H/HeJ ENSMUSG00175040127
 protein coding gene Chr13:52592451-52654556 (-)
C57BL/6NJ ENSMUSG00215036140
 protein coding gene Chr13:52623688-52685701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018579
 protein coding gene Chr13:51470829-51534468 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210030862
 protein coding gene Chr13:52797430-52859527 (-)
DBA/2J ENSMUSG00185016443
 protein coding gene Chr13:53646353-53709257 (-)
FVB/NJ ENSMUSG00205032042
 protein coding gene Chr13:52448248-52510265 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230033280
 protein coding gene Chr13:62994757-63064078 (-)
NOD/ShiLtJ ENSMUSG00190022272
 protein coding gene Chr13:52689264-52752170 (-)
NZO/HlLtJ ENSMUSG00225032960
 protein coding gene Chr13:56718140-56781046 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010038180
 protein coding gene Chr13:52332225-52393358 (-)
WSB/EiJ ENSIUOG00005020483
 protein coding gene Chr13:52116321-52178950 (-)



Homology
more
  • Human Ortholog
    MACROH2A1, macroH2A.1 histone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MACROH2A1, macroH2A.1 histone
  • Synonyms
    H2AF12M, H2AFY, H2A.y, H2A/y, MACROH2A1.1, macroH2A1.2, mH2A1
  • Links
    NCBI Gene ID: 9555
    UniProt: O75367

  • Chr Location
    5q31.1; chr5:135333609-135400023 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Macroh2a1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele are viable and fertile and display no gross phenotypic abnormalities. Mice homozygous for a different knock-out allele exhibit female-specific hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    164
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26914 NCBI Gene Model | MGI Sequence Detail 62005 C57BL/6J ±  kb
    transcript NM_012015 RefSeq | MGI Sequence Detail 1978 C57BL/6  
    polypeptide Q9QZQ8 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 5
      Other 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6325042
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 17
      Phenotypes 29
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:375943 Winkler R, et al., Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization. Sci Adv. 2025 Oct 24;11(43):eadz1242
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory