Automated description from the Alliance of Genome Resources (Release 9.0.0)
Enables several functions, including ADP-D-ribose binding activity; nucleosomal DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; regulation of NAD metabolic process; and regulation of response to oxidative stress. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of lipid metabolic process. Located in condensed chromosome. Is active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study myelodysplastic syndrome. Orthologous to human MACROH2A1 (macroH2A.1 histone).
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