GO Annotations Graph

• Symbol: Macroh2a1
• Name: macroH2A.1 histone
• ID: MGI:1349392

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0072570	ADP-D-ribose binding	ISO	J:164563
Molecular Function	GO:0072570	ADP-D-ribose binding	IDA	J:325974
Molecular Function	GO:0160002	ADP-D-ribose modification-dependent protein binding	IDA	J:325974
Molecular Function	GO:0003682	chromatin binding	IDA	J:77519
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0010385	double-stranded methylated DNA binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0031492	nucleosomal DNA binding	ISO	J:164563
Molecular Function	GO:0031492	nucleosomal DNA binding	IDA	J:219091
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:219091
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0000182	rDNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0030527	structural constituent of chromatin	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0001740	Barr body	ISO	J:164563
Cellular Component	GO:0001740	Barr body	ISO	J:89037
Cellular Component	GO:0005813	centrosome	TAS	J:77519
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000793	condensed chromosome	IDA	J:77519
Cellular Component	GO:0000228	nuclear chromosome	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0000786	nucleosome	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:325974
Cellular Component	GO:0005634	nucleus	IDA	J:79872
Cellular Component	GO:0005634	nucleus	IDA	J:220900
Cellular Component	GO:0005721	pericentric heterochromatin	ISO	J:164563
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0007549	dosage compensation	ISO	J:89307
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0071169	establishment of protein localization to chromatin	ISO	J:164563
Biological Process	GO:1902750	negative regulation of cell cycle G2/M phase transition	ISO	J:164563
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	ISO	J:164563
Biological Process	GO:1904815	negative regulation of protein localization to chromosome, telomeric region	ISO	J:164563
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:1902883	negative regulation of response to oxidative stress	IMP	J:238450
Biological Process	GO:1902883	negative regulation of response to oxidative stress	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:220524
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP	J:207792
Biological Process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO	J:164563
Biological Process	GO:0006334	nucleosome assembly	IEA	J:72247
Biological Process	GO:1903226	positive regulation of endodermal cell differentiation	ISO	J:164563
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	ISO	J:164563
Biological Process	GO:1902884	positive regulation of response to oxidative stress	ISO	J:164563
Biological Process	GO:1902884	positive regulation of response to oxidative stress	IMP	J:238450
Biological Process	GO:0019216	regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:1902688	regulation of NAD metabolic process	IDA	J:325974
Biological Process	GO:0002082	regulation of oxidative phosphorylation	IDA	J:325974
Biological Process	GO:1902882	regulation of response to oxidative stress	ISO	J:164563
Biological Process	GO:1902882	regulation of response to oxidative stress	IMP	J:238450
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563