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Map3k3 Gene Detail
Summary
  • Symbol
    Map3k3
  • Name
    mitogen-activated protein kinase kinase kinase 3
  • Synonyms
    MAPKKK3, Mekk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346874
    NCBI Gene: 26406
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105975439-106046272 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346874
 protein coding gene Chr11:105975358-106047482 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019293
 protein coding gene Chr11:109362561-109434471 (+)
A/J MGP_AJ_G0019261
 protein coding gene Chr11:104706513-104779915 (+)
AKR/J MGP_AKRJ_G0019230
 protein coding gene Chr11:107832976-107906883 (+)
BALB/cJ MGP_BALBcJ_G0019235
 protein coding gene Chr11:105108953-105182391 (+)
C3H/HeJ MGP_C3HHeJ_G0019044
 protein coding gene Chr11:108121054-108193391 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019685
 protein coding gene Chr11:112713638-112788100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017310
 protein coding gene Chr11:101989077-102057798 (+)
CAST/EiJ MGP_CASTEiJ_G0018597
 protein coding gene Chr11:109179965-109251791 (+)
CBA/J MGP_CBAJ_G0019013
 protein coding gene Chr11:117403374-117482657 (+)
DBA/2J MGP_DBA2J_G0019125
 protein coding gene Chr11:104177564-104249777 (+)
FVB/NJ MGP_FVBNJ_G0019116
 protein coding gene Chr11:103679435-103750683 (+)
LP/J MGP_LPJ_G0019195
 protein coding gene Chr11:109807034-109882635 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019146
 protein coding gene Chr11:116693483-116771518 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019722
 protein coding gene Chr11:108310127-108394853 (+)
PWK/PhJ MGP_PWKPhJ_G0018362
 protein coding gene Chr11:105270905-105343602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018153
 protein coding gene Chr11:108085973-108158477 (+)
WSB/EiJ MGP_WSBEiJ_G0018648
 protein coding gene Chr11:108285881-108358556 (+)



Homology
more
  • Human Ortholog
    MAP3K3, mitogen-activated protein kinase kinase kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K3, mitogen-activated protein kinase kinase kinase 3
  • Synonyms
    MAPKKK3, MEKK3
  • Links
    NCBI Gene ID: 4215
    neXtProt AC: NX_Q99759
    UniProt: Q99759

  • Chr Location
    17q23.3; chr17:63622415-63696305 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos before E11.5. vascular remodeling does not take place normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    30
  • cDNA Data
    153
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020700 Ensembl Gene Model | MGI Sequence Detail 70834 C57BL/6J ±  kb
    transcript ENSMUST00000002044 Ensembl | MGI Sequence Detail 3450 Not Applicable  
    polypeptide ENSMUSP00000002044 Ensembl | MGI Sequence Detail 626 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 156
      cDNA 153
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39592, MGI:109593, MGI:2144565
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
    • Latest
      J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory