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Klf4 Gene Detail
Summary
  • Symbol
    Klf4
  • Name
    Kruppel-like transcription factor 4 (gut)
  • Synonyms
    EZF, Gklf, Zie
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342287
    NCBI Gene: 16600
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:55527143-55532466 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 29.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342287
 protein coding gene Chr4:55527137-55536984 (-)
129S1/SvImJ ENSMUSG00200002390
 protein coding gene Chr4:51558770-51563773 (-)
A/J ENSMUSG00195007960
 protein coding gene Chr4:51976984-51981993 (-)
AKR/J ENSMUSG00220005126
 protein coding gene Chr4:51741629-51746638 (-)
BALB/cJ ENSMUSG00180027910
 protein coding gene Chr4:51571350-51576360 (-)
C3H/HeJ ENSMUSG00175021403
 protein coding gene Chr4:51727904-51732914 (-)
C57BL/6NJ ENSMUSG00215026709
 protein coding gene Chr4:51580116-51585439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026035
 protein coding gene Chr4:49024556-49029575 (-)
CAST/EiJ ENSTCUG00005008146
 protein coding gene Chr4:51805873-51810902 (-)
CBA/J ENSMUSG00210004499
 protein coding gene Chr4:51455849-51460858 (-)
DBA/2J ENSMUSG00185016716
 protein coding gene Chr4:51806959-51811968 (-)
FVB/NJ ENSMUSG00205012180
 protein coding gene Chr4:51068634-51073643 (-)
JF1/MsJ ENSUMUG00000009844
 protein coding gene Chr4:52018513-52023820 (-)
LP/J ENSMUSG00230003148
 protein coding gene Chr4:55353998-55359289 (-)
NOD/ShiLtJ ENSMUSG00190037656
 protein coding gene Chr4:51647441-51652450 (-)
NZO/HlLtJ ENSMUSG00225002776
 protein coding gene Chr4:59963345-59968668 (-)
PWK/PhJ ENSLUMG00010007229
 protein coding gene Chr4:50923719-50929040 (-)
SPRET/EiJ ENSMSPG00010028481
 protein coding gene Chr4:52080278-52085286 (-)
WSB/EiJ ENSIUOG00005019934
 protein coding gene Chr4:51431934-51436945 (-)



Homology
more
  • Human Ortholog
    KLF4, KLF transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF4, KLF transcription factor 4
  • Synonyms
    EZF, GKLF
  • Links
    NCBI Gene ID: 9314
    UniProt: O43474

  • Chr Location
    9q31.2; chr9:107484852-107490482 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KLF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 3 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    222 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die shortly after birth due to a skin defect that results in loss of fluids. Mutants also show a dramatic decrease in the number of goblet cells of the colon.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    172
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1136
  • Tissues
    245
  • cDNA Data
    103
  • Literature Summary
    88
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003032 Ensembl Gene Model | MGI Sequence Detail 5324 C57BL/6J ±  kb
    transcript ENSMUST00000107619 Ensembl | MGI Sequence Detail 3029 Not Applicable  
    polypeptide ENSMUSP00000103245 Ensembl | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 104
      Primer pair 14
      Other 1
      Antibodies 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36140, MGD-MRK-37337, MGI:107568
    References
    more
    • Summaries
      All 638
      Developmental Gene Expression 88
      Gene Ontology 40
      Phenotypes 222
    • Earliest
      J:34906 Shields JM, et al., Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17
    • Latest
      J:391092 Zeng W, et al., Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. Cell Prolif. 2026 Aug 6;:e70269
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory