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Birc3 Gene Detail
Summary
  • Symbol
    Birc3
  • Name
    baculoviral IAP repeat-containing 3
  • Synonyms
    Api2, cIAP2, cIAP-2, HIAP2, IAP2, MIAP2, MIHC, RNF49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197007
    NCBI Gene: 11796
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7848700-7873187 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197007
protein coding gene Chr9:7848698-7873199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034330
protein coding gene Chr9:4704652-4741506 (-)
A/J MGP_AJ_G0034308
protein coding gene Chr9:4828667-4854704 (-)
AKR/J MGP_AKRJ_G0034236
protein coding gene Chr9:4691922-4717829 (-)
BALB/cJ MGP_BALBcJ_G0034302
protein coding gene Chr9:4557818-4584244 (-)
C3H/HeJ MGP_C3HHeJ_G0034013
protein coding gene Chr9:4871685-4899859 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034824
protein coding gene Chr9:4880398-4908457 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031762
protein coding gene Chr9:4051877-4078626 (-)
CAST/EiJ MGP_CASTEiJ_G0033341
protein coding gene Chr9:4897891-4924849 (-)
CBA/J MGP_CBAJ_G0033986
protein coding gene Chr9:5020150-5060154 (-)
DBA/2J MGP_DBA2J_G0034143
protein coding gene Chr9:4690884-4716730 (-)
FVB/NJ MGP_FVBNJ_G0034088
protein coding gene Chr9:4468575-4499570 (-)
LP/J MGP_LPJ_G0034229
protein coding gene Chr9:4767327-4792766 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034132
protein coding gene Chr9:5753520-5778492 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034843
protein coding gene Chr9:4685275-4710516 (-)
PWK/PhJ MGP_PWKPhJ_G0033044
protein coding gene Chr9:4813519-4838342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032882
protein coding gene Chr9:4928682-4952291 (-)
WSB/EiJ MGP_WSBEiJ_G0033456
protein coding gene Chr9:4699054-4730212 (-)



Homology
more
  • Human Ortholog
    BIRC3, baculoviral IAP repeat containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIRC3, baculoviral IAP repeat containing 3
  • Synonyms
    AIP1, API2, c-IAP2, CIAP2, HAIP1, HIAP1, IAP-1, MALT2, MIHC, RNF49
  • Links
    NCBI Gene ID: 330
    neXtProt AC: NX_Q13489
    UniProt: Q13489

  • Chr Location
    11q22.2; chr11:102317484-102339403 (+)  GRCh38

Human Diseases
more
  • Diseases
    5 with human BIRC3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a reduced susceptibility to endotoxic shock. Mice homozygous for a knock-in allele exhibit increased B cell survival and proliferation, lymph node hyperplasia, lymphocytic infiltrates in the lungs, and enlarged gut-associated lympoid tissue.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032000 Ensembl Gene Model | MGI Sequence Detail 24488 C57BL/6J ±  kb
    transcript ENSMUST00000013949 Ensembl | MGI Sequence Detail 2667 Not Applicable  
    polypeptide ENSMUSP00000013949 Ensembl | MGI Sequence Detail 602 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 2
      cDNA 115

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143290
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:30406 Rothe M, et al., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52
    • Latest
      J:342656 Schorn F, et al., cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. 2023 Nov 15;42(22):e113614

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory