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Htr2a Gene Detail
Summary
  • Symbol
    Htr2a
  • Name
    5-hydroxytryptamine (serotonin) receptor 2A
  • Synonyms
    5-HT2A receptor, Htr-2, Htr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109521
    NCBI Gene: 15558
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:74878314-74944299 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.37 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1907 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109521
 protein coding gene Chr14:74878280-74946934 (+)
129S1/SvImJ ENSMUSG00200009368
 protein coding gene Chr14:63308096-63376765 (+)
A/J ENSMUSG00195003877
 protein coding gene Chr14:63454751-63523437 (+)
AKR/J ENSMUSG00220007086
 protein coding gene Chr14:62844920-62920090 (+)
BALB/cJ ENSMUSG00180020284
 protein coding gene Chr14:63046794-63115468 (+)
C3H/HeJ ENSMUSG00175027933
 protein coding gene Chr14:64865962-64941139 (+)
C57BL/6NJ ENSMUSG00215015180
 protein coding gene Chr14:63042074-63110744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019505
 protein coding gene Chr14:65539741-65605662 (+)
CAST/EiJ ENSTCUG00005028730
 protein coding gene Chr14:64692228-64767482 (+)
CBA/J ENSMUSG00210010136
 protein coding gene Chr14:63480864-63556054 (+)
DBA/2J ENSMUSG00185021781
 protein coding gene Chr14:68625420-68700601 (+)
FVB/NJ ENSMUSG00205020110
 protein coding gene Chr14:62865851-62934535 (+)
JF1/MsJ ENSUMUG00000034848
 protein coding gene Chr14:79776020-79846277 (+)
LP/J ENSMUSG00230011884
 protein coding gene Chr14:80658212-80726866 (+)
NOD/ShiLtJ ENSMUSG00190010523
 protein coding gene Chr14:63239226-63307892 (+)
NZO/HlLtJ ENSMUSG00225039602
 protein coding gene Chr14:70967261-71042480 (+)
PWK/PhJ ENSLUMG00010010619
 protein coding gene Chr14:62642615-62711312 (+)
SPRET/EiJ ENSMSPG00010024271
 protein coding gene Chr14:66282119-66347390 (+)
WSB/EiJ ENSIUOG00005022764
 protein coding gene Chr14:62621062-62696274 (+)



Homology
more
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR2A, 5-hydroxytryptamine receptor 2A
  • Synonyms
    5-HT2A, HTR2
  • Links
    NCBI Gene ID: 3356
    UniProt: P28223

  • Chr Location
    13q14.2; chr13:46831546-46898082 (-)  GRCh38
Human Diseases
more
  • Diseases
    13 with human HTR2A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 5 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    136
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    125
  • cDNA Data
    12
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15558 NCBI Gene Model | MGI Sequence Detail 65986 C57BL/6J ±  kb
    transcript NM_172812 RefSeq | MGI Sequence Detail 2937 ZRU/MplStud  
    polypeptide P35363 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 13
      cDNA 14
      Primer pair 5
      Other 1
      Antibodies 5

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10998, MGD-MRK-11007, MGD-MRK-39520
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 17
      Gene Ontology 14
      Phenotypes 41
    • Earliest
      J:10923 Hsieh CL, et al., The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov;16(6):567-74
    • Latest
      J:391298 Wen Y, et al., Targeting peripheral 5-HT(2A)R enhances antitumor immunity in colorectal cancer. Cell. 2026 Aug 4;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory