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Nkx3-2 Gene Detail
Summary
  • Symbol
    Nkx3-2
  • Name
    NK3 homeobox 2
  • Synonyms
    Bapx1, Nkx-3.2
Location &
Maps
more
  • Sequence Map
    Chr5:41918826-41921563 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 22.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108015
 protein coding gene Chr5:41918826-41921844 (-)
129S1/SvImJ ENSMUSG00200028051
 protein coding gene Chr5:37414893-37417919 (-)
A/J ENSMUSG00195028331
 protein coding gene Chr5:36821368-36824386 (-)
AKR/J ENSMUSG00220002014
 protein coding gene Chr5:36845244-36848262 (-)
BALB/cJ ENSMUSG00180023686
 protein coding gene Chr5:36650982-36654000 (-)
C3H/HeJ ENSMUSG00175018675
 protein coding gene Chr5:38614312-38617330 (-)
C57BL/6NJ ENSMUSG00215004689
 protein coding gene Chr5:37372479-37375497 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027187
 protein coding gene Chr5:36379174-36382201 (-)
CAST/EiJ ENSTCUG00005023814
 protein coding gene Chr5:36763794-36766829 (-)
CBA/J ENSMUSG00210004674
 protein coding gene Chr5:37582169-37585187 (-)
DBA/2J ENSMUSG00185016605
 protein coding gene Chr5:39490053-39493071 (-)
FVB/NJ ENSMUSG00205014003
 protein coding gene Chr5:36415817-36418835 (-)
JF1/MsJ ENSUMUG00000001186
 protein coding gene Chr5:44061830-44064868 (-)
LP/J ENSMUSG00230002283
 protein coding gene Chr5:44114033-44117059 (-)
NOD/ShiLtJ ENSMUSG00190002635
 protein coding gene Chr5:36656899-36659917 (-)
NZO/HlLtJ ENSMUSG00225015375
 protein coding gene Chr5:49310192-49313218 (-)
PWK/PhJ ENSLUMG00010022004
 protein coding gene Chr5:36711891-36714929 (-)
SPRET/EiJ ENSMSPG00010029608
 protein coding gene Chr5:38008639-38011546 (-)
WSB/EiJ ENSIUOG00005017803
 protein coding gene Chr5:39561657-39564683 (-)



Homology
more
  • Human Ortholog
    NKX3-2, NK3 homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX3-2, NK3 homeobox 2
  • Synonyms
    BAPX1, NKX3.2, NKX3B, SMMD
  • Links
    NCBI Gene ID: 579
    UniProt: P78367

  • Chr Location
    4p15.33; chr4:13540830-13547744 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 7 alleles in 5 genetic backgrounds
    32 phenotypes from multigenic genotypes
    5 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are perinatal lethal, lack a spleen, and display skeletal dysplasia of the vertebral column and cranium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1029
  • Tissues
    248
  • cDNA Data
    14
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12020 NCBI Gene Model | MGI Sequence Detail 2738 C57BL/6J ±  kb
    transcript NM_007524 RefSeq | MGI Sequence Detail 1437 Not Specified  
    polypeptide P97503 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 3
      cDNA 15
      Primer pair 8
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37050
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 51
      Diseases 2
      Gene Ontology 15
      Phenotypes 63
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:374859 Torres-Cano A, et al., Spatially organized cellular communities shape functional tissue architecture in the pancreas. Sci Adv. 2025 Nov 14;11(46):eadx5791
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory